5-Year Impact Factor: 0.9
Volume 35, 12 Issues, 2025

Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Important Announcement for Trainees

"A companion journal of JCPSP (the official journal of CPSP) has been launched by the name of JCPSP Postgraduate (JCPSP PG). Submissions to JCPSP PG will be open from March 01, 2025"
For more details, Please visit https://jcpsppg.pk/.

Latest Articles
Volume 35 | Issue 4 | April 2025
Environment-Conscious Imaging

By Saba Sohail


The Optimal Dosage of the Nalbuphine Preemptive Analgesia on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy: A Randomised, Controlled, Double-Blind Study

By Peng Chen, Honghua Wang, Dajin Liu, Xu Jing

ABSTRACT Objective: To investigate the optimal dosage of nalbuphine preemptive analgesia on pain after laparoscopic cholecystectomy. Study Design: A double-blind, randomised study. Place and Duration of the Study: Department of Anaesthesiology, The Affiliated Huai’an Hospital of Xuzhou Medical...

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Influence of Nasolabial Angle on Facial and Smile Attractiveness

By Afeefa Abul Barakaat, Kanza Tahir, Rashna Hoshang Sukhia, Mubassar Fida

ABSTRACT Objective: To identify the effect of the nasolabial angle (NL) on smile and facial profile attractiveness. Study Design: A cross-sectional study. Place and Duration of the Study: Department of Surgery, Section of Dentistry (Orthodontics), The Aga Khan University Hospital, Karachi, Pakistan...

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Advanced Radiomics for Predicting Extracapsular Invasion of Metastatic Axillary Lymph Nodes in Breast Cancer Patients Using CT Imaging

By Erkan Bilgin, Ezel Yaltirik Bilgin, Ahmet Bayrak, Sahap Torenek

ABSTRACT Objective: To evaluate the efficacy of radiomics features extracted from computed tomography (CT) images in predicting extracapsular invasion (ECI) of metastatic axillary lymph nodes in breast cancer patients. Study Design: Observational study. Place and Duration of the Study: Department o...

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Genetic Association Between Hypothyroidism and the Risk of Trigeminal Neuralgia: A Two-Sample Mendelian Randomisation Study

By Changyou Yin, Wei Zhao, Wei Kong, Yue Lv, Yan Bin Wang

Abstract Objective: To use Mendelian randomisation (MR) for determining the causal relationship between hypothyroidism and trigeminal neuralgia (TN). Study Design: Analytical study.                    ...


Expression, Prognosis, and Functional Analysis: KDM5B in Acute Myeloid Leukaemia (Non-M3)

By Na Lu, Xiaoke Huang, Xiaolin Liang, Qin Li, Yuling Xu, Zhenfang Liu

ABSTRACT Objective: To investigate the value of Lysine Demethylase 5B (KDM5B) in the prognosis and immunity of acute myeloid leukaemia (AML). Study Design: A case-control study. Place and Duration of the Study: Department of Haematology, The First Affiliated Hospital of Guangxi Medical University, ...

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Difference in Frequency of Aeroallergen Hypersensitivity in Patients from Urban Versus Rural Households

By Muhammad Hussain, Muhammad Omair Riaz, Mustajab Alam, Muhammad Aftab Hassan, Muhammad Zain Arshad

ABSTRACT Objective: To indirectly evaluate the hygiene hypothesis in the Pakistani population by assessing the difference in aeroallergen hypersensitivity frequency among patients from urban and rural households. Study Design: Cross-sectional, descriptive study. Place and Duration of the Study: Depa...


Association of Serum Folate and Homocysteine Parameters in Diabetic Patients with and Without Foot Ulcer

By Saleem Ullah Abro, Qamer Aziz, Iftikhar Ahmed, Zahid Miyan, Asher Fawwad, Mohammad Kamran Azim

ABSTRACT Objective: To assess the association of serum folate and homocysteine parameters in diabetic patients with and without foot ulcers. Study Design: A comparative study. Place and Duration of the Study: Department of Physiology, Baqai Medical University, Karachi, Pakistan, from June 2023 to 20...

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T2D and Osteoporosis Risk: A Mendelian Randomisation Study

By Zhenming Zeng, Zhenzhen Wang, Xiahai Zheng, Tao Jiang, Min Shao, Yong Lian

ABSTRACT Objective: To investigate the causal effect of Type-II Diabetes (T2D) on osteoporosis (OP) risk using a two-example Mendelian randomisation (MR). Study Design: Descriptive study. Place and Duration of the Study: Third School of Clinical Medicine, Guangzhou University of Traditional Chinese...

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Outcomes of Hepatic Venoplasty in Budd-Chiari Syndrome

By Adnan Salim, Khurram Shafique, Sadia Jabbar, Zia Ur Rehman, Kashif Malik

ABSTRACT Objective: To observe medium to long-term outcomes of hepatic venoplasty in patients with Budd-Chiari syndrome (BCS). Study Design: An observational study. Place and Duration of the Study: Department of Gastroenterology and Radiology, Shaikh Zayed Hospital, Lahore, Pakistan, from February ...


Prognostic Value of SOX9, E-Cadherin, and KLF4 Expressions in Clear Cell Renal Carcinoma

By Seyma Ozturk, Selma Erdogan Duzcu

ABSTRACT Objective: To analyse the immunohistochemical staining of stem cell-related factors SOX9 and KLF4 in radical and partial nephrectomy specimens and to determine their relationship to grade, metastasis, stage, other prognostic parameters, and their predictive value. Study Design: Descriptive ...

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Comparison of Visual Outcome of Successful Descemet Membrane Endothelial Keratoplasty and Penetrating Keratoplasty

By Teyyeb Azeem Janjua, Anam Hassan, Waqar Muzaffar, Shagufta Parveen, Muhammad Shahid, Jawwad Ahmad

ABSTRACT Objective: To compare the visual outcome in patients undergoing penetrating keratoplasty (PKP) with descemet membrane endothelial keratoplasty (DMEK). Study Design: A quasi-experimental study. Place and Duration of the Study: Department of Eye, The Armed Forces Institute of Ophthalmology, ...

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Effect of Modified Frailty Index on Postoperative Outcomes after Total Knee Arthroplasty

By Muhammad Omer Farooq, Mahnoor Tariq, Ahsan Sulaiman, Shahryar Noordin

ABSTRACT Objective: To determine the impact of the modified frailty index (MFI) on patient-reported outcome measures (PROMs) using the knee injury and osteoarthritis outcome score (KOOS-12) following total knee arthroplasty (TKA). Study Design: Prospective-observational study. Place and Duratio...


Systemic Immune-Inflammation Index in Assessing Disease Activity and Extraglandular Involvements in Primary Sjogren’s Syndrome

By Ozlem Kilic, Mehmet Nur Kaya, Duygu Tecer, Sedat Yilmaz

ABSTRACT Objective: To evaluate if the systemic immune inflammation index (SII) predicts extraglandular involvement and disease activity in primary Sjogren’s Syndrome (pSS). Study Design: Cross-sectional, observational study. Place and Duration of the Study: Department of Rheumatology, Univers...

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Sevoflurane vs. Propofol Anaesthesia and the Risk of Perioperative Acute Kidney Injury

By Mingjuan Li, Wenli You, Xiaosa Chi, Maomao Nie, Anmu Xie

ABSTRACT Sevoflurane has been suggested to lower the incidence of acute kidney injury (AKI) after heart surgery compared to intravenous anaesthetics. However, recent studies indicated opposite results. Therefore, this meta-analysis was conducted on randomised controlled trials (RCTs) to determine if...


Effects of PCSK9 Inhibitors on Glucose Metabolism in Hyperlipidaemic Patients: A Meta-Analysis

By Yujie Bai, Miao Hu, Jiayan Zhang, Ling Zhou

ABSTRACT This review assessed the impacts of PCSK9 inhibitors on glucose metabolism in patients with dyslipidaemia. A comprehensive search was conducted using PubMed, Embase, Cochrane Library, and ClinicalTrials.gov to find randomised controlled studies investigating the indicators of glucose metabo...

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Effectiveness and Safety of Memantine Add-on Treatment for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis

By Wenxuan Zhang, Yuhan Zhang, Enyan Yu

ABSTRACT Obsessive–compulsive disorder (OCD) is a highly disabling mental illness characterised by repetitive thoughts and behaviours that disrupt daily life and impair social functioning. The purpose of this meta-analysis was to assess the efficacy and safety of memantine augmentation in trea...


Artificial Intelligence in Medical Education

By Muhammad Farooq, Ambreen Usmani

ABSTRACT Objective: To explore the understanding of medical students regarding the integration of AI in medical education. Study Design: Mixed methods, explanatory sequential study. Place and Duration of the Study: This study was conducted from March to May 2024 at the CMH Medical College, Lahore, P...


Outcomes of Autologous Haematopoietic Stem Cell Transplant in Lymphomas: A Single Centre Study

By Irsa Hidayat, Mehreen Ali Khan, Munazza Nabi Awan, Awais Siddiq, Noor Shamim, Hashim Khan

ABSTRACT Objective: To determine the outcomes of autologous haematopoietic stem cell transplant (auto HSCT) in lymphoma patients in terms of overall survival (OS), disease-free survival (DFS), and treatment-related mortality and to identify the associated factors. Study Design: A descriptive study....


Outcome of Haematopoietic Stem Cell Transplant in Beta-Thalassaemia Major: Single Centre Experience from a Low- and Middle-Income Country

By Hashim Khan, Tariq Ghafoor, Nighat Shahbaz, Tariq Azam Khattak, Uzma Rahim, Munazza Nabi Awan

ABSTRACT Objective: To determine the outcome of haematopoietic stem transplant (HSCT) in beta-thalassaemia major (BTM) patients. Study Design: Descriptive Study. Place and Duration of the Study: Department of Clinical Haematology, Armed Forces Bone Marrow Transplant Centre (AFBMTC), Rawalpindi, Paki...


Musculoskeletal Ultrasound in the Diagnosis and Interventional Management of Common Pain Disorders - Analysis from a Physiatry Pain Clinic

By Sarah Razaq, Muhammad Aleem Arshad, Waseem Iqbal

ABSTRACT Objective: To determine the practical applications of musculoskeletal ultrasound (MSK US) in the precise diagnosis and optimal interventional management of painful musculoskeletal conditions within Physical Medicine and Rehabilitation (PMR) clinics in Pakistan. Study Design: An observation...


Opening the Dialogue: A First-of-Its-Kind Exploration into Ethics of Termination of Pregnancy

By Arshad Khushdil, Muhammad Fayyaz, Madiha Ahmad, Afeera Afsheen, Imran Ahmad, Zeeshan Ahmed

ABSTRACT Objective: To evaluate the perspectives and practices of Paediatricians and Obstetricians in Pakistan regarding termination of pregnancy (TOP). Study Design: A cross-sectional survey. Place and Duration of the Study: Department of Paediatrics, Pak Emirates Military Hospital, Rawalpindi, Pa...


MALDI-TOF-MS Application in M-Protein Detection and Its Associations with Clinical Laboratory Findings in Geriatrics

By Jing Cheng, Yuying Zhang, Mingjie Cao, Yun Sun, Xiaomin Lv, Haiya Wang

ABSTRACT Currently, the methods used to detect M-protein such as SPEP (serum M-protein electrophoresis), IFE (immunofixation electrophoresis), and sFLC (serum free light chain) assay are hyposensitive, laborious, time-consuming, and expensive. In this study, the authors assessed the performance of M...


Adherence to Practice Guidelines for Postoperative Epidural Analgesia

By Sami Ur Rehman, Muhammad Malik, Adeel Sabir, Abdul Rehman, Eesha Rehman

ABSTRACT Objective: To evaluate the adherence to practice guidelines for epidural insertion along with the medicines used for postoperative analgesia and the incidence of complications. Study Design: Clinical audit. Place and Duration of the Study: Doctors Hospital and Medical Centre, Lahore, Pakist...


Association Between C-Reactive Protein and Suicidal Ideation: A Large-Scale Cross-Sectional Study

By In Cheol Hwang, Hong Yup Ahn, Yujin Park

ABSTRACT Studies of C-reactive protein (CRP) levels and suicidal behaviours have shown inconsistent results previously. This study investigated the relationship between CRP levels and suicidal ideation in a large population-based cohort in Korea to enhance the understanding of the biological aspect...


Gender Differences in Cigarette Smokers' Exhaled Carbon Monoxide and Nicotine Dependency Levels

By Izzet Fidanci, Cansu Alici Yilmaz, Hilal Aksoy, Duygu Ayhan Baser

ABSTRACT The purpose of this study was to determine whether smoking behaviour, exhaled carbon monoxide (CO) levels, and addiction status differ between male and female smokers. The data of the applicants to the smoking cessation outpatient clinic were retrospectively examined to complete the study. ...


Utilisation of Erector Spinae Catheter-Based Analgesia Practice in Thoracic Surgery Patients

By Sami Ur Rehman, Naila Qamar, Aleena Kashif


Langerhans Cell Histiocytosis in Cervical Vertebra 4 in an Obese Man

By Yaya Zhou, Zongbo Zhang, Wendong Xie, Chao Zhang


Total Knee Arthroplasty Combined with Ligament Reconstruction for the Treatment of Severe Knee Valgus Deformity and Knee Subluxation with Medial Collateral Ligament Injury

By Hanlei Li, Wendong Xie, Zhiqi Zhang


Healthcare under Fire: Violations of International Laws in Gaza

By Hanin Hicazi Ridvan, Seyma Handan Akyon, Adem Ozkara


Surgery in Type I Aortic Dissection: Is Simple the Best?

By Ayhan Muduroglu, Demir Cetintas