Epub Ahead of Print

A case with neonatal onset Type 2 Neuronal Ceroid Lipofuscinosis: A novel mutation

By Ozgun Uygur, Mehmet Yekta Oncel, Pinar Gencpinar, Burcu Ozturk Hismi, Merve Saka Guvenc, Nihal Olgac Dundar,

Neuronal Ceroid Lipofuscinosis (NCL) is a lysosomal storage disorder that causes progressive neurodegenerative disease as a result of storage in neuro...


MULTIMODAL IMAGING OF OPTIC NERVE DRUSEN IN A HYPEROPIC CHILD

By Sehnaz Ozcaliskan, Ozgur Artunay,

Optic nerve drusen (OND) are abnormal calcified acellular deposits located within the prelaminar portion of the optic nerve. They are usually asymptom...


Late diagnosis of Paracetamol poisoning is always lethal in young adult

By Sehrish Naz, Safia Fatima, Muhammad Aamir,

Acetaminophen has a remarkable safety profile when prescribed in proper therapeutic doses but hepatotoxicity can occur when misused or after an overdo...


Radiologic findings of scapular langerhans cell histiocytosis successfully treated with CT guided corticosteroid injection

By Cennet Sahin, Burcin Agridag Ucpinar, Yunus Oc, Fevziye Kabukcuoglu,

Although Langerhans Cell Histiocytosis (LCH) may arise from any bone, flat bones (skull, ribs, scapula, clavicle, and mandible) are more commonly invo...


Control of Refractory Hypercalcemia with Denosumab in a case of Metastatic Parathyroid Carcinoma

By Murat Çalapkulu, Ozen Oz Gul, Soner Cander, Canan Ersoy, Erdinc Erturk, Muhammed Fatih Sagiroglu, Ozlem Saraydaroglu,

Parathyroid carcinoma is a rare cause of hyperparathyroidism and leads to severe hypercalcemia. The etiology is not fully known. Parathyroid cancer sh...


Unilateral Optic Neuropathy Due To a Sphenoid Mucocoele

By Sana Nadeem, Amir Akbar, Aasma Nudrat Zafar,

Isolated sphenoid sinus mucocoeles are rare, benign lesions usually discovered incidentally. They can present with headache, diplopia, visual loss or ...


Snail Fever of The Bladder In A Non-Endemic Area – A Case Report From Pakistan

By Zehra Kazmi, Muhammad Areeb Ashfaq, Daniya Umer, Romana Idress, Muhammad Hammad Ather,

Schistosomiasis is rarely seen in Pakistan and is generally not very high on the list of differential diagnoses. However, it is an important cause of ...


What can be done for Large and Multiple Choledochal Stones?

By Ufuk Arslan, Haci Murat Cayci, Ali Tardu, Umut Eren Erdogdu,

Endoscopic retrograde cholangiopancreatography may fail to extract large and multiple choledochal stones in a single session, necessitating a repeat p...


Myxoid Liposarcoma with Cartilagenous Differentiation – A Case Report

By Hina Tariq, Tariq Sarfraz, Iqra Saeed,

Myxoid liposarcoma (MLPS) is an adipocytic tumour and second commonest among the types of liposarcoma. It exhibits a wide histological spectrum. It is...


Anaesthesia Management of a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency Undergoing Total Thyroidectomy: A Case Report

By Muhammad Yasir, Anwar Ul Huda,

We present anaesthesia management of a patient having Glucose-6-phosphate dehydrogenase (G6PD) deficiency who underwent thyroidectomy. The main concer...


A case of systemic lupus erythematosus with malignant pleural mesothelioma in a 42-year woman

By Yunyun Liu, Jianlin Tong, Xuefeng Ling, Wa Cao, Dr Leifang,

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by inflammation. Malignant pleural mesothelioma (MPM) is a...


Superficial Thrombophlebitis Caused By Extensively Drug Resistant Salmonella Enterica Serovar Typhi

By Anam Imtiaz, Irfan Ali Mirza, Qanita Fahim, Nargis Sabir,

Salmonella enterica serovar Typhi causes one of the most common blood stream infections, the typhoid fever. However, it can cause pyogenic infections ...


Malignant melanoma metastasis to sigmoid colon; new endoscopic appearance detected for the first time

By Ugur Kesici,

Malignant melanoma (MM) develops as a result of malignant transformation of melanocytes. It accounts for 4% of all skin cancers. MM metastases usually...


Silver-Russell Syndrome- Orthodontic Perspective

By Zahra Khalid, Kashif Iqbal, Abdullah Jan, Asif Khurshid,

Silver-Russell syndrome (SRS) is a rare disorder characterized by prenatal and postnatal growth deficiency, a relatively large head size with triangul...


Video-assisted thoracoscopic right inferior lobe resection for bronchial mucoepidermoid carcinoma in a 10-year child: A case report

By Fan Yang,

Bronchial mucoepidermoid carcinoma is a rare disease in the field of thoracic surgery, and it is even more rarer in children. A 10-year Chinese child ...


T-Cell Lymphoma Presenting With Bilateral Chylothorax: A Rarity

By Ibrahim Ethem Özsoy, Mehmet Akif Tezcan,

Chylothorax is the accumulation of chyle in the pleural cavity due to obstruction or injury arising in the thoracic duct or its large branches. In mor...


Thinking of Unilateral Osteitis Condensans Ilii in the emergency room: case of a young pregnant female with back pain

By Sadaf Sheikh, Umair Javed, Muhammad Akbar Baig,

Osteitis Condensans Ilii (OCI) remains an orthopedic diagnostic dilemma; moreover, such presentation in the emergency room (ER) is unique. Limited awa...


Hemophagocytic Lymphohistiocytosis (HLH) In a Pediatric Patient: A Case Report

By Saad Waheed, Saima Gillani,

Hemophagocytic Lymphohistiocytosis (HLH) is an uncommon but a potentially fatal disease characterized by high grade fever, hepato-splenomegaly, derang...


Primary Intraarticular and Extraarticular Sinovial Chondromatosis in a Child: A rare cause of Shoulder Pain in Children

By Burcin Agridag Ucpinar, Cennet Sahin,

Synovial chondromatosis is a rare condition with chondroid metaplasia of the synovial membrane and multinodular proliferation of the synovial membrane...


CT-Guided Percutaneous Radiofrequency Ablation of Osteoid Osteoma With Double Nidi In One Session: A Case Report

By Cennet Sahin, Eyup Camurcuoglu, Mehmet Ali Talmac, Mujdat Bankaoglu, Kerim Sahin,

Osteoid osteoma with multiple nidi is a rare condition. Aim of this report is to share a case of an osteoid osteoma with two separate nidi which under...


Nerve-preserving cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for advanced primary caecal cancer invading pelvic side-wall: Report of a case with right leg limping

By Ethem Unal, Abdullah Yildiz, Sema Yuksekdag,

Radical surgery to achieve optimal cytoreduction in locally advanced caecal cancer can dictate femoral or sciatic nerve resection, especially in cases...


Anaesthetic management of Tracheal injury following Blunt Neck trauma – An Unusual Late Presentation

By Muhammad Saad Yousuf, Mohammad Bin Pervez, Saulat Fatimi, Khalid Samad,

Tracheal injuries following blunt neck trauma are life threatening surgical emergencies with high risk of mortality. A high index of suspicion is nece...


A Rare Complication Chylous Ascites after Aortobifemoral Bypass Surgery

By Görkem Yiğit, Alp Yildirim, Mustafa Ozdemir, Anil Ozen, Hakki Zafer Iscan,

Injury of the lymphatic trunk during abdominal aortic surgery causes leakage of chyleinto the peritoneum resulting in chylous ascites. A 53-year male,...


AN OLD ENEMY: STILL NEPHROTOXIC

By Faruk Recep Ozalp, Tugba Karadeniz, Alper Alp,

Tubulointerstitial nephritis (TIN) presents histopathologically as tubulitis and oedema/inflammation and fibrosis affecting the renal tubules and inte...


Brain Abscess caused by Lactococcus Lactis in a young male

By Intisar Ahmed, Kashif Aziz, Hameed Tareen, Muhammad Arslan Ahmed,

Lactococcus lactis cremoris is one of the gram positive cocci, not known to be pathogenic in humans. We report a case of brain abscess due to Lactococ...


Acute Hepatitis A Virus Infection as a Rare Cause of Hemophagocytic Lymphohistiocytosis: A Case Report

By Ali Dogan, Sinan Demircioglu, Omer Ekinci,

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the mononuclear phagocytic system characterized by histiocyte and lymphocyte activation...


Painless Posterior Scleritis ; A rare Presentation

By Summaya Khan, Mahum Faheem, Imran Basit, Ammarah Ashraf,

Posterior scleritis is an underdiagnosed condition due to its rarity and a misdiagnosed condition due to its varied presentation.1 Therefore, it is im...


Assessment of Look-Alike, Sound-Alike & Read-Alike (LASARA) Medicine – Errors in Pharmacy

By Rubia Zafar, Muhammad Liaquat Raza,

Objective: To estimate chances of potential look-alike, sound-alike and read-alike (LASARA) errors in Secondary-care hospital pharmacies throu...


Spectacle Cord Retained Oculo-Orbital Prosthesis: A Case Report

By Shefali Goel, Saumyendra V Singh, Neetu Singh, Deeksha Arya, Pooran Chand,

Retention of an orbital prosthesis plays a key role in treatment success and patient acceptance as does aesthetics. Though numerous retentive aids are...


Effects of mode and duration of exercises on Fat mass of obese Population

By Batool Hassan, Sumaira Imran Farooqui, Muhammad Usman Khan, Ali Farhad, Qurat Ul Ain Adnan,

A meta-analysis was performed to determine impact of resistance and aerobic exercise on body fat of obese population. Database of Google Scholar, BioM...


Embolization of The Coronary Arterial Tree With Thick Contrast Material During Coronary Angiography: A Case Report

By Waleed M Ghaleb, Abdelfatah Elasfar, Mohsen Alarbash, Abdulrahman Aldiri-, Abdulhalim Jamal Kinsara,

A 58-year male was referred to our center with an acute inferior ST elevation myocardial infarction (STEMI). During the primary percutaneous coronary ...


Changes in Serum Protein and Enzyme Levels in Human T Lymphotropic Virus-1-Infected Patient

By Amer Abdulrahman Almaiman,

This study aims to evaluate the changes in serum protein levels in a patient with confirmed human T lymphotropic virus type-1 (HTLV-1) infection. Scre...


Littoral Cell Angioma of the spleen presenting with thrombocytosis and splenic infarct

By Nazmi özer, Alper Sozutek,

Littoral cell angioma is a non-hematologic vascular neoplasm originating from littoral cells lining the splenic red pulp. The diagnosis is usually mad...


Sarcoidosis Presenting With Bilateral Optic Disc Edema As The Initial Presentation: A Case Report

By Merve Beyza Yildiz, Sevcan Balci, Sehnaz Ozcaliskan, Ece Turan Vural,

Sarcoidosis is a chronic, progressive, granulomatous inflammatory disease of unknown etiology that affects multiple organ systems. Granulomatous anter...


Familial Amyloidotic Polyneuropathy Type 1 – A Hereditary Legacy

By Joel Pinto, Paulo Almeida, Flavio Pereira, Susana Cavadas,

Familial amyloidotic polyneuropathy type 1 (FAP 1) is a systemic autosomal dominant amyloidosis associated with transthyretin mutation. It is characte...


challanges in management of multiple splenic abscesses caused by Extensively Drug Resistant (XDR)salmonella typhi

By Ch Muhammad Zubair, Muhammad Ameer Musa, Muhammad Musa Haider, Zulfiqar Ali Khosa,

Extensively drug-resistant (XDR) Typhoid emerged in Hyderabad, Pakistan in 2016. It spread regionally and globally due to fast travelling. An immuno-c...


Primitive Neuroectodermal Tumor of the Testis: A Case Report and Review of Literature

By Tarık Demir, Altay Aliyev, Mesut Seker, Cevper Ersoz, Ganime Coban, Haci Mehmet Turk,

A 21-year male presenting with left testicular mass and retroperitoneal lymphadenopathy underwent radical orchiectomy; and his pathological examinatio...


Acute Mono-appendicitis in a Case of Duplex Appendix: a rare finding

By Ahmet Akbaş, Nadir Adnan Hacım, Fatih Daşıran, Hasan Dagmura, Emin Daldal,

Appendiceal duplication is an extremely rare entity in adulthood. It is usually diagnosed incidentally during laparotomy performed for another indicat...


Challenges in Retrorectal Cysts: is Preoperatıve Dıagnosıs Essentıal?

By Kursat Rahmi Serin, Onder Karabay, Nadir Adnan Hacım, Mustafa Cem Terzi,

Developmental cysts are a subgroup of perirectal cysts seen extremely rarely. They have no symptoms in 50% of cases, and mostly occur among middle-age...


Effect of General and Non-general Anesthesia on Postoperative Cognitive Dysfunction

By Yue Gao, Lian Liu, Bo Zhao, Yafeng Wang, Shihua Yu, Huaxin Wang,

Controversy exists in the effect of general anesthesia and non-general anesthesia on postoperative cognitive dysfunction (POCD). The authors aimed to ...


The Role of Serum Laboratory Biomarkers for Complicated and Uncomplicated Appendicitis in Adolescents

By Serkan Sengul, Yilmaz Guler, Hasan Calls, Zulfikar Karabulut,

Objective: To investigate if serum biomarkers could differentiate complicated and uncomplicated appendicitis in adolescents. Study Design: An cross ...


Postoperative Cognitive Dysfunction following General Anaesthesia in patients undergoing Elective Non-cardiac Surgery

By Muhammad Saad Yousuf, Khalid Samad, Dr Hameedullah,

Objective: To determine frequency of early postoperative cognitive dysfunction (POCD) in patients aged 40 to 60 years, following general anaesthesia i...


ATP7B Mutation Analysis: Wilson Disease, A Difficult to Diagnose case

By Muhammad Almas Hashmi, Bibi Zubaida, Rai Muhammad Asghar, Munir Akmal Lodhi,

Wilson’s Disease (WD) is a common metabolic disorder predominantly involving liver, brain, and eyes. Pancreatic, renal, psychiatric, and cardiac inv...


Feasibility of Interval-Compressed Chemotherapy for Pediatric Ewing Sarcoma

By Haleema Saeed, Rishm Ali, Saadiya Javed Khan,

A retrospective chart review was conducted to determine the feasibility of interval-compressed chemotherapy regimen in pediatric Ewing sarcoma (ES) pa...


Follicular Sensitivity Index: A Tool to Predict Successful Conception After Intra-cytoplasmic Sperm Injection

By Rehana Rehman, Amara Zafar, Nida Zahid, Nuruddin Mohammad,

Follicular sensitivity index (FSI) is used for estimation of follicular responsiveness to controlled ovarian hyperstimulation (COH) during intra-cytop...


Isolated Female Epispadias with Urinary Incontinence

By Shahzad Ali, Hira Moosa, Saeed Ahmed Khan Narejo,

Isolated female epispadias without bladder extrophy is a rare variant of female urethral anomaly reported rarely in the literature. For optimal and ea...


Clinical Application of the FICE Technique For Biopsy Of Bronchial Mucosal Lesions

By Qing Zhang, An-na Su, Na Liu, Xiao-han Wang, Chang Liu, Qin-yao Zhang,

Objective: To determine the diagnostic accuracy of flexile spectral imaging color enhancement (FICE) of abnormal morphologic changes in bronchial muco...


Sarcoidosis Presenting as Fatigue and Weakness

By Syed Muhammad Zubair, Naveed Haroon Rashid,

Sarcoidosis is a systemic granulomatous disorder of unknown cause that occurs in both men and women of all races. It typically presents in patients af...


Peripheral Giant Cell Granuloma of posterior maxilla in a nine year old child. A case report

By Hamza Hassan Mirza, Abul Khair Zalan, Anser Maxood, Anika Gul, Zainab Memon, Muhammad Sulaiman,

Peripheral giant cell granuloma is a relatively uncommon benign reactive gingival lesion of the oral cavity. A 9-year boy presented with a painless, s...


CLADOPHIALOPHORA BANTIANA AS A CAUSE OF RARE FUNGAL BRAIN ABSCESS: A CASE SERIES

By Usama Rehman, Zafar Ali, Fatima Anwar, Muhammad Usman,

Cerebral phaeohyphomycosis refers to Central Nervous System infection caused by dematiaceous molds, which have many genuses. Cladophialophora bantian...


Management of A Firmly Lodged Endotracheal Tube: A Case of High Quality Communication

By Gabrielle Thompson, Mark Harrison, Hassan Ahmad,

This article describes a case of endotracheal tube firmly lodged in the trachea of a patient due to denuded subglottic cartilage and subglottic swelli...


Parachute mitral valve: anatomy and operation

By Shi-min Yuan,

Parachute mitral valve is a rare congenital heart defect characterised by a distorted mitral geometry with a single papillary muscle for all mitral ch...


Spectrum of Addison’s Disease in Children

By Taj Muhammad Laghari, Mohsina Noor Ibrahim, Zubair Khoso, Misbah Iqbal Hanif, Meher Un Nisa, Jamal Raza,

Objective:  To determine the clinical presentation of Addison’s disease in order to increase the awareness of presentation in Pakistani children. ...


Damage Control Surgery Saves Patient With Gastric Lymphoma From Radical Gastrectomy

By Gang Chen, Min-min Zhang, Jun-min Zhu, Jie Mao, Yu-min Li,

The concept of damage control surgery was first introduced in the 1990s. It has great significance in the treatment for critically ill patients, which...


Surgical Treatement of Gastric GIST: Feasibility of Laparoscopic Resection and Postoperative Outcome

By Costache Mircea Florin, Filip Bogdan, Lupascu Cristian, Trofin Ana Maria, Danciu Mihai, Scripcariu Viorel,

Objective: The aim of this study is to evaluate clinical manifestations and the possibility of laparoscopic treatment of large gastric stromal tumors....


Bortezomib-based Triplet Regimens for Remission Induction in Multiple Myeloma

By Saima Humayun Toor, Tariq Mahmood Satti, Raheel Iftikhar, Syed Kamran Mahmood, Ghassan Umair Shamshad, Jahanzeb Ur Rehman,

Objective: To compare the efficacy and side effect profile of different bortezomib-based triplet regimens for remission induction in patients with mul...


Harmonic Scalpel for Internal Mammary Artery Harvest

By Shi-min Yuan,

Internal mammary artery (IMA) harvest by using a harmonic scalpel for coronary artery bypass grafting (CABG) have not been sufficiently evaluated. Thi...


Effect of Phototherapy on Peripheral Blood Cells in Hyperbilirubinemic Newborns

By Abdullah Kurt, Merve Sezen Tosun, Nilgün Altuntaş, Sarı Erol,

This study was conducted to determine the neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, platelet/lymphocyte ratio; and to evaluate the effec...


Polycystic Ovary Syndrome, Subfertility and Vitamin D Deficiency

By Arfa Azhar, Fatima Abid, Rehana Rehman,

Polycystic ovarian syndrome (PCOS) is the most common endocrine female disorder, affecting 4-18% women of reproductive age. The prevalence of PCOS in ...


Mycobacterium Abscessus: A Rare Cause of Peri-Ductal Mastitis in Endemic Regions

By Aisha Nabeel, Lubna Mushtaque Vohra,

Mycobacterium abscessus is a rapidly growing non-tuberculous, multi-drug resistant mycobacterium (NTM). Its common clinical presentation includes pulm...


Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations

By Sundarachary Nagarjunakonda, Rajeswari Daggumati, Sridhar Amalakanti,

Hyperargininemia is a urea cycle disorder that has rarely been reported in adults. We present a case of arginase deficiency disorder in a 32-year man ...


Therapeutic Plasma Exchange Combined with Total Thyroidectomy to Rescue a Case of Thyroid Storm Intolerant to Antithyroid Drugs

By Xiaoxia Hu, Haidong Wang, Jie Li, Hong Shi, Xia Liu, Jirui He,

Thyroid storm is a syndrome related to acute exacerbation of thyrotoxicosis for which timely diagnosis and treatment are crucial. Importance of antith...


Seroprevalence of Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) In District Vehari, Pakistan

By Muhammad Zeeshan Ahmed, Haseeba Shahzad, Tazeen Rao, Aleema Ali, Noreen Samad,

The aim of the study was to evaluate the prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV) in districtVehari, Pakistan; and to highlig...


Lateral Supraorbital Approach for the Surgical Clipping of Ruptured Tiny Anterior Circulation Aneurysms

By Tao Jiang, Lili Yan, Mingyu Chen, Junfei Cao, Yanjie Shen, Zhenhua Ren,

Objective: To evaluate the efficacy and usefulness of clipping procedure by lateral supraorbital approach for tiny anterior circulation aneurysms. St...


Primary renal leiomyosarcoma

By Changyi Quan, Yunshen Ding,

To optimise the diagnosis and treatment of primary renal leiomyosarcoma, we present    our experience with a similar case and review the literature...


Novel inflammation biomarkers in patients with mycosis fungoides treated with bexarotene

By Funda Tamer, Ayla Gulekon,

Mycosis fungoides (MF) is a skin lymphoma characterized by atypical T lymphocyte infiltration which may present with patches and tumors in advanced st...


Adenocarcinoma in orthotopic neobladder 19 years after radical cystoprostatectomy

By Orkunt Ozkaptan, Alkan Cubuk, Erdinc Dincer, Osman Murat Ipek,

Radical cystectomy and orthotopic neobladder are the most preferred surgical approaches for the treatment of invasive bladder cancer. Secondary tumour...