5-Year Impact Factor: 0.9
Volume 35, 12 Issues, 2025

Epub Ahead of Print

Association Between Mental Health and Metabolic Dysfunction–Associated Fatty Liver Disease

By Ji Hyeon Park, Yoo Jeong Lee, In Cheol Hwang, Hong Yup Ahn,

Depression has recently been suggested as a novel predisposing factor for metabolic dysfunction–associated fatty liver disease (MAFLD) among US adul...


Impact of Hands-on Cadaveric Dissection Courses on the Improvement of Surgical Skills of Ear, Nose and Throat Surgeon; A Survey from the Consultants and Postgraduate Trainees

By Saleh Khurshied, Altaf Hussain, Mujahid Raza, Nawal Khurshid, Maesum Ali, Mehrunnisa Nawaz,

A cross-sectional observational study at Pakistan Institute of Medical Sciences, PIMS Islamabad from April 2023 to May 2024 to determine the impact of...


Integration of Digital Modality in Virtual Classroom Enhances Nursing Students’ Inclusiveness in Learning: A Game Based Approach

By Sanam Hanif, Rabab Vadivala,

COVID-19 and virtual learning were transformative changes for educators and students in nursing education. This rapid shift necessitated educators to ...


The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus

By Saadiya Siddiqui, Ayesha Chatta, Faria Altaf,

The aim of this study was to evaluate the efficacy of 0.2% topical hyaluronic acid in management of symptomatic oral lichen planus (OLP). This prospec...


Comprehensive Evaluation of Peripheral Blood Count Parameters in Donor Deferral Practices: Its Utility as a Quality Control Tool in Blood Banking Services

By Helen MARY Robert, Zunairah Mughal, Noman Anjum Rana, Intzar Ali, Sumaira Ilyas, Ayesha WAHID Mian,

This study assessed the role of peripheral blood counts in donor deferral and its utility as a quality control measure in blood banking. Conducted ret...


Development and validation of a tool to evaluate dental residents’ understanding and satisfaction with their post-graduate summative assessment.

By Syed Murtaza Raza Kazmi, Fakeha Azhar Syed, Tabassum Zehra,

Students’ comprehension of the assessment process is critical for a successful evaluation. The authors at the Aga Khan University Hospital, develope...


Complete Remission in BCLC stage C Hepatocellular Carcinoma Treated with HAIC Combined with PD1 Inhibitors and Anti-angiogenic Therapy

By Shitao Lu, Yapan Guo, Wencong Feng, Jun Yang, Yu Yin, Zhi Li,

Hepatocellular carcinoma (HCC) at BCLC stage C poses substantial therapeutic challenges and is typically associated with a poor survival prognosis. Th...


OCCURRENCE OF PARAFUNCTIONAL HABITS IN ADULTS WITH AND WITHOUT TEMPOROMANDIBULAR DISORDER

By Ateeqa Younis, Nadia Zaib, Maira Tafzeel, Muqaddas Zafar, Hajra Habiba, Sameen Aamir,

The objective of the study was to determine the occurrence of parafunctional habits in adults with and without temporomandibular disorder. It was a cr...


The Educational Application of Teacher-made Mind Maps on Students

By Jin-lan Zhou, Shan-qin Wang, Kai-deng Hong, Ren-jiao Cai, Jing Chen, Xing-Wei Zhe,

This study's purpose was to look into the potential educational applications of teacher-made mind maps on the students. This is a single-group wit...


Efficacy of Sofosbuvir and Daclatasvir Combination Treatment in Chronic Hepatitis C in Patients Among Haemodialysis Patients

By Sindhya Memon, Pooran Mal, Joti Seetlani, Aimen Yousuf, Shahnaz Rahimoon, Neelam Memon,

The aim of this study was to determine the effectiveness of Sofosbuvir and Daclatasvir (SOF/DCV) combination treatment in hemodialysis patients with c...


An insight into Chronic Laparoscopic Port Site Infections: A Systematic review

By Muhammad Tahir Ghani, Ibad Ur Rehman, Nain Sukh Dr, Burhan Tariq, Arif Khurshid, M Ali Aadwani,

Chronic laparoscopic port site infections (PSI) are known to be caused by non-tuberculous mycobacterium (NTM). The aim of this systematic review was t...


Rivaroxaban versus enoxaparin for the prevention of venous thromboembolism and wound complications after total knee arthroplasty:A systematic review and meta-analysis

By Shasha He, Xiangbao Yin, Yingqi Xu, Zhiwei Zhong,

A systematic review was conducted to compare rivaroxaban and enoxaparin in preventing venous thromboembolism (VTE) and wound complications after total...


Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Titration in Acute Respiratory Distress Syndrome: A Meta-Analysis

By Mumu Fan, Yunnan Hu, Peirong Zhang,

This study explored the effectiveness of an electrical impedance tomography (EIT)-based positive end-expiratory pressure (PEEP) titration strategy com...


Medical students’ deaths by suicide in Pakistan: An alarming trend and a Call for Action

By Sania Mumtaz Tahir, Muhammed Omer, Ahmad Nawaz, Nazish Imran,

Suicide among medical students is a serious issue. To understand the pattern and risk factors of medical students’ deaths by suicide, a Google searc...


Imaging features and clinicopathology of adenoid cystic carcinoma of the head and neck

By Wanyi Shao, Yingyu Dai, Shan Huang, Yonghao Liu,

Adenoid cystic carcinoma (Adenoid cystic carcinoma, ACC) is relatively rare in head and neck tumours, and the early imaging features are not specific,...


Nicotine dependence as a prognostic factor for glycemic control in non-diabetic smokers: A nationwide Korean survey

By Ji Hyeon Park, Yoo Jeong Lee, In Cheol Hwang, Hong Yup Ahn,

This study examined the independent relationship between nicotine dependence and glycaemic indices among non-diabetic smokers. Data of 672 non-diabeti...


Beyond the waves: Assessment of the clinical appropriateness of electroencephalography referrals in neurological practice

By Noor Fatima, Safia Bano, Ahmad Nawaz, Muhammad Imran Malik, Muhammad Usman Choudhary, Ahsan Numan,

This cross-sectional study evaluated the appropriateness of EEG referrals at the Department of Neurology, Mayo Hospital and King Edward Medical Univer...


Robotic assisted cholecystectomy – our experience of first 156 robotic cholecystectomies performed on Versius robotic platform from Pakistan

By Usman Ismat Butt, Mahmood Ayyaz, Muhammad WARIS Farooka, Muhammad Umar,

Objective: To determine the console time and safety of robotic assisted cholecystectomy on the Versius system. Design: Observational study Place a...


The correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with per-operative findings in acute appendicitis

By Faran Hamid, Saeed Bin Ayaz, Muhammad Asif, Muhammad Nabeel Imran, Adnan Mehraj, Naheed Akhtar,

Objective: To ascertain whether the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are reliable diagnostic tools for acut...


Can Serum B-hCG Values Measured Following Embryo Transfer Predict Live Birth at Similar Values in Both Fresh and Frozen Transfers?

By Burak Elmas, Serap Topkara Sucu, Berrin Goktug Kadoglu, Mustafa Ozturk, Ozlem Ozturk, Seyit Temel Ceyhan,

Objectives: The present study aimed to determine the threshold B-hCG values ​​that can predict the live birth rates in IVF-ET cycles and to compar...


FREQUENCY OF SARCOPENIA IN COPD PATIENTS

By Sukriye Gundogdu, Halil Ibrahim Yakar, Handan Inonu Koseoglu, Ahmet Cemal Pazarli, Gokhan Aykun,

Objective: To investigate the frequency of sarcopenia in COPD patients and the control group, and compare the 6-minute walk test (6MWT), handgrip stre...


A DEEP LEARNING APPROACH FOR DETECTING PERIAPICAL LESIONS IN PANORAMIC RADIOGRAPHIC IMAGES

By Mert Yagiz Pekiner, Hakan Yulek, Ayse Gul Oner Talmac, Gaye Keser, Filiz Namdar Pekiner, Ibrahim Sevki Bayrakdar,

Objective: To assess the performance of a deep learning method for apical lesion segmentation on dental panoramic radiographs. Study Design: Onservat...


Optimizing the Management of Diabetic and Non-Diabetic Patients Hospitalized with Community-Acquired Pneumonia: The Efficacy of Multiplex Respiratory PCR Testing

By Orhan Dalkilic, Selami Aydin, Bekir Sami Uyanik, Suveyda Gozukucuk,

Objective: To compare the positivity rates of pathogens detected in diabetic and non-diabetic pneumonia cases, assess the role of the Multiplex Respir...


Evaluation of Hypermobility in Rhinoplasty: A Case-Control and Cross-Sectional Study

By Omer Faruk Kocak, Mahmut Alpayci, Canser Yilmaz Demir, Server Ilter, Nazim Bozan,

Objective: To determine the frequency and severity of hypermobility in rhinoplasty and to assess rhinoplasty satisfaction in rhinoplasty cases with hy...


DeepSeek-R1 in Clinical Medicine: Advancing AI-Driven Diagnostics, Decision Support, and Medical Education

By Yuhui Chen, Shousen Wang,

DeepSeek, a rising artificial intelligence (AI) company in Hangzhou, China, introduced DeepSeek-R1, an advanced reasoning model that rivals top large ...


Effectiveness of Video-Based Instructions On Urostomy Self-Care in Patients Undergoing Radical Cystectomy and Ileal Conduit Urinary Diversion

By Arshad Maqbool, Wajahat Aziz, Shahid Iqbal, M Hammad Ather,

Objective: To evaluate the effectiveness of video-assisted stoma care teaching in improving patients' confidence and skills in stoma management. ...


Clinical Utility of Ultrasound-Guided Midline Catheters in Cardiovascular Intensive Care Unit

By Fen Xu, Tao Xiang, Liang Hui Zhang, Ling Liang, Feng Liu, Xiongfei Xu,

This observational study evaluated the clinical utility of ultrasound-guided midline catheters (MCs) for cardiovascular medicine delivery in a cardiov...


Simulation based training for Limberg Flap Technique for Pilonidal Sinus through task trainer: Strategy to enhance surgical skills.

By Dr. Rubab Nafees, Dr Rabia Aftab, Dr. Komal Faheem, Dr. Madeeha Shahid, Dr Aun Ali,

Intergluteal pilonidal sinus is a common disease of adults especially males and is related with high morbidity. The rhomboid flap reconstruction for p...


Comparıson of Open Mesh (Lıchensteın) and Laparoscopıc (Tep-Tapp) Technıques in Prımary Unılateral Inguınal Hernıa

By Ali Sapmaz, Serhan Yilmaz, Cenk Ozkan, Canbert Celik, Hatice Telci, Eda Sahingoz,

Objective: To evaluate the safe and effective treatment for inguinal hernia and compare the short- and long-term outcomes of open mesh repair and lapa...


Ventilator Associated Pneumonia as Biggest Challenge: Incidence, Risk Factors, Prevention and Mortality Rate

By Sami Ur Rehman, Unaiza Saeed,

This cross-sectional study was done in Surgical ICU of Doctors Hospital and Medical Centre, Lahore, Pakistan from 1st January to 31st December 2023, t...


Empowering health care professionals with the innovative ‘five tips’ approach.

By Dr Sara Shakil, Dr. Rabia Aftab, Dr. Azam Afzal, Dr. Shazia Babar, Muhammad Tariq,

In the era of information bombardment, it is mandatory to adopt the ability to receive new information and apply it in respective context. Healthcare ...


Non-Communicable Diseases and Their Implications in Pregnant Women- Results from a Cross-Sectional Study in Pakistan

By Dr Naima Shirazi, Dr Huda Sarwar, Afifa Tanweer,

Non communicable diseases (NCDs) during pregnancy can have detrimental outcomes for the mother-child pair. An analytical cross-sectional study was con...


Evaluating trends of Voluntary Non-Remunerated Blood Donors and Replacement Blood Donors: Prevalence of Transfusion Transmitted Infections in Healthy Donors—Insights from Malakand Division (2021-2024 Retrospective Study)

By Syed Muzammil Shah, Sultan Ahmad, Noor Elahi, Muhammad Tariq, Shahid Alam, Tahir Shah,

Objective: To evaluate the trends in voluntary non-remunerated blood donors (VNRBD) versus replacement donors, and investigate the prevalence of trans...


AI Tools in Medical Research and Writing: Balancing Innovation and Critical Thinking in Young Researchers and Students

By MUHAMMAD FAROOQ AZAM RATHORE, Fareeha Farooq,

Artificial intelligence (AI) tools are being integrated into medical research and writing at a rapid pace ever since ChatGPT was launched in November ...


Construction and Validation of a Risk Prediction Model for Immune-Related Adverse Events in Patients Receiving Immunosuppressants for Lung Cancer

By Yitao Chen, Xiaoyu Xiang, Lichun Wang, Runmei Wang,

Objective: To examine the factors influencing immunogenic adverse reactions (irAEs) in lung cancer (LC) patients undergoing treatment with immune chec...


Effectiveness of Cross-Spreader Graft Technique in Crooked Nose Surgery

By Ömer Erdağ,

Objective: To evaluate the effectiveness of cross-spreader graft technique (CSGT) in I-shaped crooked nose surgery. Study design: Retrospective obser...


A Novel Acetabular Biplanar Calibration Method in Establishing Hip Arthroscopic Portals

By Qilong Jiang, Yu Deng,

Objective: To introduce a novel acetabular biplanar calibration (ABC) method to improve the accuracy of hip arthroscopic portal establishment. Study ...


War Fare Injuries: A Case-Series of Retained Foreign Bodies in The Genitourinary Tract

By Liaqat Ali, Shehzad Faiz, Fareeha Afridi, Faiza Hayat,

Objective: To present the largest case series on the management of retained foreign bodies in the genitourinary system resulting from warfare, bomb bl...


Development and Validation of a Nomogram for Predicting Progression-Free Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with Anlotinib

By Zhengyu Wu, Peng Zhou, Yanan Zhao, Junping Wang, Shan Gao,

Objective: To determine the factors influencing progression-free survival (PFS) in patients with advanced non-small cell lung cancer (NSCLC) undergoin...


Comparison of Classical Blood Cardioplegia and Modified Del Nido Cardioplegia on Postoperative Serum Lactate, and Extubation Times.

By Burak Tamtekin, Güler Gülsen ERSOY,

Objective: This study aimed to compare the effects of intermittent classical blood cardioplegia and single-dose modified Del Nido cardioplegia in coro...


Facilitators, barriers and recommendations for overcoming barriers to HIV self-testing (HIVST) among men who have sex with men and transgender in Asia; a qualitative evidence synthesis.

By Safdar Kamal Pasha, Usman Ali,

This paper aimed to identify the facilitators, barriers, and recommendations for overcoming barriers to HIVST uptake for men who have sex with men (MS...


Enhancing Comprehension of Intraoral Radiographic Techniques Through Innovative Approaches

By Suresh Kandagal Veerabhadrappa, Jayanth Kumar Vadivel, Seema Yadav,

Intraoral radiographs are essential for diagnosis and treatment planning in clinical dentistry. Therefore, mastering these radiographic techniques is ...


Role of n-acetylcysteine in the prophylaxis against contrast induced nephropathy: A meta-analysis

By BABAR RAFIQUE, Abdul Rehman Arshad, Sohail Sabir, Umair Ijaz, Obaid Ur Rahman,

This study aimed to determine the effect of n-acetylcysteine in preventing contrast-induced nephropathy. Literature search was carried out on PubMed a...


A Meta-Analysis :PTEN Expression in Relation to Prognosis and Clinical Characteristics of Patients with Colorectal Cancer

By Xiaoli Zhang, Huiguang Chen, Qingming Wu,

The incidence and mortality of colorectal cancer (CRC) are steadily rising. PTEN (Phosphatase and TENsin homolog deleted on chromosome 10) expression ...


Venlafaxine versus other medications for preventing migraine:An Updated meta-analysis and Trial Sequential Analysis

By Ju Gao, Guangming Xia, Tian Yu, Guanglin Wang, Lei Wang,

This meta-analysis with trial sequential analysis (TSA) evaluated venlafaxine's efficacy in migraine prevention through database searches from the...


Meta-analysis of Risk Factors for Positive Pathology Results Following Second Transurethral Resection for Non-muscle Invasive Bladder Cancer

By Jiashuo Li, Yidi He, Shuai Wu,

To systematically evaluate the risk factors associated with positive pathology results following second transurethral resection (re-TUR) in patients w...


COVID-19 Epidemic-The Turning Point of Ending Chinese Doctors’ Sudden Cardiac Death

By Wei Xiong, Yongmin Shi Shi, Xiyun Rao, Qingwen Yu, Mingwei Wang, Jiake Tang,

Sudden cardiac death (SCD) is a public health problem that affects the all ages and social groups in the world. SCD is an unexpected sudden death caus...


EVALUATION OF TEMPOROMANDIBULAR JOINT BONE DEGENERATIONS USING CONE BEAM COMPUTED TOMOGRAPHY in KENNEDY CLASS I and CLASS II PARTIALLY EDENTULOUS PATIENTS

By Hakan Yulek, Gaye Keser, Filiz Namdar Pekiner, Suay Yağmur ünal,

Objective: To assess temporomandibular joint (TMJ) osseous degenerations in Kennedy Class I and II partially edentulous patients using cone beam compu...


Bleomycin-lipiodol emulsion combined with polyvinyl alcohol particles in the treatment of focal nodular hyperplasia of the liver: initial experience and literature review

By Yan Wang, Wei-hao Zhang, Yong-fei Guo, Zhi-gang Tian, Mao Yang, Tong-guo Si,

The purpose of this study was to explore the feasibility, effectiveness and safety of bleomycin-lipiodol emulsion combined with polyvinyl alcohol part...


A COMPARATIVE ANALYSIS OF MINIMALLY INVASIVE SURGICAL METHODS IN ESOPHAGECTOMY: A REVIEW STUDY.

By Ifeanyi Christian Onyebuchi, Shaojin Zhu, You Qi, Guangjie Hou, Ifeanyi Christian Onyebuchi,

This study compared the clinical efficacy and practicality of inflatable transcervical mediastinoscopic esophagectomy (TIME) versus minimally invasive...


Is the classification of Ventilator-Associated Pneumonia as early and late-onset useful?: A comparison of microbial profile, antibiotic susceptibility and mortality

By Sami Ur Rehman, Unaiza Saeed, Hussnain Bin Saeed, Saran Ghani, Arshad Taqi,

Objective: To determine the microbial profile, antibiotic susceptibility, and mortality rates of early vs late-onset ventilator-associated pneumonia (...


Uncinate Processes Inner Margins Guide Quick and Mid-line Placement of Multilevel Plate on Cervical Vertebra with Severe Osteophyte and Technique Notes

By Jingyun Wang, Fei Tan, Wei Xie, Qilin Lu,

A 60-year male patient diagnosed with cervical spondylotic myelopathy and dysphagia had a prior history of diffuse idiopathic skeletal hyperostosis (D...


Low-Dose Tamoxifen for Breast Noninvasive Disease: A Meta-Analysis

By Na Wang, Li Li Gong, Gang Hu, Mei Chun Ye,

Tamoxifen is a classic endocrine therapy for breast cancer, but conventional doses of tamoxifen have serious side effects. Hence, it is crucial to pri...


Palliative care in the Emergency Department: A step in the right direction

By Sarah Afzal Kothari, Muhammad Atif Waqar, Shahan Waheed,

Palliative care, as defined by the World Health Organization (WHO), focuses on improving the quality of life for patients facing life-limiting illness...


Dedicated Brain Injury Rehabilitation Units need in Pakistan

By Muhammad Tawab Khalil, Sarah Razaq, MUSAB BIN NOOR, Fahim Anwar,

Brain injuries are an increasing healthcare problem in Pakistan.  Despite the growing burden of head injuries, there are few specialized brain injury...