5-Year Impact Factor: 0.9
Volume 35, 12 Issues, 2025

Epub Ahead of Print

Bleomycin-lipiodol emulsion combined with polyvinyl alcohol particles in the treatment of focal nodular hyperplasia of the liver: initial experience and literature review

By Yan Wang, Wei-hao Zhang, Yong-fei Guo, Zhi-gang Tian, Mao Yang, Tong-guo Si,

The purpose of this study was to explore the feasibility, effectiveness and safety of bleomycin-lipiodol emulsion combined with polyvinyl alcohol part...


Palliative care in the Emergency Department: A step in the right direction

By Sarah Afzal Kothari, Muhammad Atif Waqar, Shahan Waheed,

Palliative care, as defined by the World Health Organization (WHO), focuses on improving the quality of life for patients facing life-limiting illness...


Symptoms, Triggers and Prodromes of Hereditary Angioedema in Pakistani Population

By Muhammad Hussain, Muhammad Omair Riaz, Mustajab Alam, Hamid Nawaz Tipu, Muhammad Aftab Hassan,

This cross-sectional observational study, conducted from September 2021 to December 2024 at the Department of Immunology, Armed Forces Institute of Pa...


Development of the Kyphosis Cardiopulmonary Resuscitation (K-CPR) Technique in Patients with Spinal Mobility Restriction Due to Ankylosing Spondylitis

By Hasan Sultanoğlu, Tuba Erdem Sultanoğlu,

Patients with ankylosing spondylitis (AS) often present with spinal rigidity and kyphotic deformity, which may hinder conventional cardiopulmonary res...


HCV Seropositivity Versus Care Non-compliance in Shenzhen Blood Donors

By Yizhong Liu, Chenghui Huang, Yingkun Wang, Caiyue Fang, Jie Zhao, Sheng Zhang,

This retrospective cross-sectional analysis assessed hepatitis C virus (HCV) prevalence, demographics, and post-diagnosis management among 220,990 vol...


Factors Predicting Cognitive Dysfunction End Stage Renal Disease

By Saman Shuja Khan, Abdul Rehman Arshad, Muhammad Iqbal, Nushra Maqsood,

This observational study probed into different factors potentially associated with cognitive impairment in patients aged 40 to 80 years on maintenance...


A Meta-Analysis of HIV Drug Resistance in Pakistan

By Shafee Ur Rehman,

HIV drug resistance (HIVDR) creates a threat to the extended success of antiretroviral therapy (ART) while making it harder to control the HIV epidemi...


Age-stratified Association between Health Literacy and Unmet Medical Needs among Korean Adults

By Ki Dong Ko, In Cheol Hwang, Hong Yup Ahn,

Identifying the factors associated with unmet medical need (UMN) is critical for designing interventional strategies. This nationwide cross-sectional ...


Exploring Body Dysmorphic Disorder: A Cross-Sectional Survey

By Saadiya Siddiqui, Faria A, Wajeiha Saeed, Ashba Nasir Cheema, Rashid Ali, Bushra Bashir,

The aim of this descriptive, quantitative cross-sectional survey was to find the prevalence and explore different demographic characteristics of body ...


Mind-Motor Mat Training as an Early Adjunct to Anti-Hypertensive Therapy for Cognitive Preservation

By Sana BASHIR, Arzoo Bashir, Mehreen Baig,

Hypertension affects over 1.28 billion adults globally and remains a critical contributor to cardiovascular complications, mortality, and cognitive de...


Renal Sympathetic Denervation Plus Pulmonary Vein Isolation for Atrial Fibrillation with Hypertension: A Meta-Analysis of RCTs

By Kun Wang, Na Yi, Yong Cai Liang, Jie Xiong, Ting Wan,

Background: This study aimed to assess the efficacy and safety of adding adjuvant renal sympathetic denervation (RSDN) to pulmonary vein isolation (PV...


Factors Associated with The Survival of Head and Neck Cancer Patients: A Single Institution Experience from Karachi, Pakistan

By UZMA SHAMSI, Namra Usman, Zeerak Jarrar, Romana Idress, Iqbal Azam,

The objective of the study was to examine the clinicopathological features and survival rates of head and neck cancer (HNC) patients, from the Aga Kha...


Psychological Care in Heart Failure Rehabilitation: A Systematic Review and Meta-Analysis

By Ruigui Zheng, Zhe Xue, Yijian YU,

This meta-analysis aimed to evaluate the efficacy of psychological therapy versus conventional therapy within cardiac rehabilitation programs for indi...


A Novel Metric to Guide Cancer Priorities in Pakistan

By Aashir Aslam, Syed Nabeel Zafar,

Pakistan faces an escalating cancer burden, with approximately 185,748 new cases and 118,631 deaths annually. According to GLOBOCAN data, breast cance...


Screening of Predictive Variables for Severe Hyperlipidemic Acute Pancreatitis

By Gongchao Yu, Zhenxing Li, Kunfeng Yan, Xiaorong Dai, Qingyu Zhang,

This retrospective observational study aimed to identify risk factors and screen predictive variables for severe hyperlipidemic acute pancreatitis (HL...


Appropriateness of Antibiotic Dosing in Patients with Augmented Renal Clearance in Cardiovascular Surgery and Coronary Intensive Care Units

By Ayşe Gül KoÇoĞlu Kinal, Yunus Emre AYHAN,

Objective: To evaluate the appropriateness of antibiotic dosing in patients with augmented renal clearance (ARC) admitted to cardiovascular surgery (C...


Patterns of Vascular Calcification and Stenosis in Peripheral Artery Disease: A CTA-Based Study of Disease Severity and Treatment Decisions

By Dr Athar Badshah, Dr Muhammad Ismail, Brig Dr Nauman Imtiaz, Brig Dr Ahsin Manzoor Bhatti, Dr Anas Bin Saif, Dr Mustansar Hussain Haidri,

Peripheral artery disease (PAD), a systemic form of atherosclerosis, causes limb ischemia, with disease severity critically determined by vascular cal...


Prevalence of Cancer in Pakistan: A Meta-Analysis

By Shafee Ur Rehman,

Cancer continues to grow as a major public health issue in Pakistan because its occurrence and death rates keep increasing. The development of cancer ...


Study on Endoscopic Spine Surgery in The Treatment of Degenerative Lumbar Spondylolisthesis With Spinal Stenosis in the Elderly

By Chongchao Yan, Genwei Liu, Na Zhong, Zhongxu Bai, Jianpeng Zhang, Wenkui Zhao,

Objective: To analyze the clinical outcomes of endoscopic lumbar interbody fusion for the treatment of degenerative lumbar spondylolisthesis with spin...


The Clinical Efficacy of Local versus Intramuscular Injection of Methotrexate in the Treatment of Cesarean Scar Pregnancy: A Meta-Analysis

By Peipei Zhou, Huihui Sun, Jingjie Song, Yunxia Ke,

This meta-analysis were designed to compare of the clinical efficacy of local injection and systemic intramuscular injection of methotrexate in the tr...


Intraoperative Colonoscopy-Guided Localisation of Proximal Resection Margin in Sphincter-Preserving Surgery for Rectal Cancer After Neoadjuvant Chemoradiotherapy

By Qiao Zhang, Shenghui Wang, Xianda Qiu, Xingrong Lu, Pan Chi, Zhifen Chen,

The study was conducted to evaluate the feasibility and efficacy of intraoperative colonoscopy-guided proximal resection margin (PRM) localisation in ...


Serum Retinol Binding Protein 4 Levels Among Hypertensive and Normotensive Individuals

By Kiran Iftikhar, Muhammad Husnain, Noor Sehar, Muhammad Ahmad Malik, Saqib Sohail,

The aim of this cross-sectional study was to compare serum Retinol Binding Protein 4 (RBP4) levels in hypertensive and normotensive non-obese individu...


Mini-Mental State Examination Changes and Prediction of Cognitive Recovery after Stroke Following Cognitive-Motor Intervention

By Hu Chen, Jingyuan Lin,

Objective: To evaluate the impact of cognitive-motor intervention on cognitive function in stroke patients and to explore predictive factors for meani...


The Effect of Skin Tag Presence on Medical Treatment Success in Chronic Anal Fissure Patients

By Fikret Calikoglu, Zeliha Aydn Kasap, Tugba Koc Calikoglu, Kubra Isik, Ahmet Akbas,

To determine whether skin tag is important in the success of treatment in patients with chronic anal fissure who received conservative treatment with ...


Evaluating CKD-EPI Pakistan Against Standard Equations Using DTPA-Measured GFR

By Muhammad Shahzil, Nayyar Saleem, Muhammad Rashid Asghar, Aimon Riaz, Noor Ul Ain, Ahmed Sheraz,

Objective: To evaluate and compare the accuracy of creatinine-based equations (CKD-EPI Pakistan, CKD-EPI 2021, MDRD) against the gold-standard DTPA c...


Effects of Probiotics on Oral Microbiological Environment, Gingival Health, and Dental Plaque- A Meta-Analysis

By MEHWASH KASHIF, Mahmooda Kazmi, Asfahan Shah, Syeda Nimra Qadri,

This meta-analysis was conducted to assess the effects of probiotics on dental plaque and gingival health and oral microbiological environment. The Pu...


New Insights into Controlled Intracranial Decompression for Preventing Traumatic Acute Brain Bulge

By Liang Xian, Shilong Fu, Ye Dan, Long Lin, Shousen Wang,

Traumatic acute brain bulge is a life-threatening phenomenon. Traumatic acute brain bulge is usually classified into primary brain bulge and secondary...


The Clinical Value of Neuropsychiatric Scales in The Preliminary Identification of Frontotemporal Dementia from Alzheimer's Disease

By Lingfeng Zhang, Pengxing Lin, Yipan Zhang, Zhijian Lin,

Objective: To provide reference for the clinical differentiation of behavioral variant of Frontotemporal dementia(bvFTD) and Alzheimer’s disease(AD)...


Development of a Machine Learning Model for Predicting Postoperative Pain after Root Canal Treatment

By Zhijun Wei, Sheng Feng, Han Zheng, Qiong Sun, Fuhua Zhang, Lei Zhang,

Objective: To develop and validate a machine learning (ML) model to predict postoperative pain following root canal treatment (RCT). Study Design: Ob...


Identification and Clinical Consensus Evaluation of Drug-Drug Interactions in Cardiac Intensive Care Units

By Ayşe Gül Kocolu Kinal, Yunus Emre AYHAN,

Objective: To evaluate the frequency characteristics, and clinical relevance of potential drug-drug interactions (pDDIs) in Cardiovascular Surgery Int...


Ireland’s ADM (Capacity) Act 2015: Essential insights for International Medical Practitioners

By Shankar Lal, Ehtesham Khan,

Assisted decision-making (ADM) frameworks signify a revolutionary change in healthcare law and ethics, incorporating autonomy, dignity, and participat...


Harnessing Artificial Intelligence to Restore Medical and Dental Education Standards in Pakistan

By Orooj Bashir, Syeda Kashaf Abbas, Javed Ashraf,

Pakistan’s medical and dental education has experienced declining standards, inconsistent regulation, and periodic loss of recognition of degrees. T...


Effects of High Intensity Aerobic Interval Training Versus Continuous Aerobic Training in Heart Failure Patients

By Hafiza Misbah Inayat, Muhammad Iqbal Tariq, Mehwish Waseem, Ayesha Khalid, Farheen Khan, Muhammad Asad,

The study was conducted to determine the effects of high intensity aerobic interval training versus continuous aerobic training in heart failure patie...


Magnifying Endoscopy Versus Endoscopic Ultrasound for Assessment of the Invasion Depth in Superficial Esophageal Squamous Cell Carcinoma: A Meta-Analysis

By Ruihong Chen, Wei Yang, Biao Yang, Dou Fu, YuanFa Li,

Both magnifying endoscopy(ME) and Endoscopic ultrasound(EUS) are applied for assessment of invasion depth in superficial esophageal squamous cell carc...


Association Between Oral Health Status and Oral Frailty in Older Inpatients

By Qiang Ren, Weican Chen, Bingjie Zhang,

Objective: This study aimed to investigate the relationship between oral health status and oral frailty in older inpatients, provide a basis for the e...


Cardıovascular Death Risks and Cardıovascular Risk Awareness in Hypertensıve Individuals

By Kubra Karadag, Hilal Aksoy, Izzet Fidanci, Duygu Ayhan Baser,

Objective: In the study, it was aimed to determine the cardiovascular death risks of individuals and awareness about cardiovascular disease risk facto...


Pediatric Bone Marrow Transplant Outcomes

By Dr Asghar Ali Kerio, Dr Uzair Ahmad, Dr Shahazad Sarwar, Dr Hafiz Muhammad Nadeem, Dr Muhammad Afzal, Dr Maria Riaz,

Objective: To evaluate the clinical outcomes in pediatric post bone marrow transplant (BMT) patients, including overall survival, post-transplant comp...


Sepcturm of Microorganisms Responsible for Chronic Suppurative Otitis Media

By Fahad Hasnain, HAMAD-UR-REHMAN , Bakhteen Ullah, Aftab Ahmad, Muhammad Tariq, Halla Saboor,

Chronic suppurative otitis media (CSOM) is a persistent infection of the middle ear characterized by tympanic membrane perforation and chronic ear dis...


Implementation of Case-Based Integrated Learning (CBIL) in Undergraduate Anaesthesiology Rotation

By Dr Rabia Aftab, Dr Rahila Ali, Dr Aliya Ahmed, Dr Hina Zahid, Dr Saima Rashid,

Case-based integrated learning (CBIL) is an innovative pedagogical approach collaboratively designed by clinical faculty and medical educationists to ...


Healthcare Simulation in Pakistan - The Need of the Hour

By Faisal Wasim Ismail,

Simulation based education is an established approach that is increasingly important in enhancing the competency of the health care workforce and impr...


Endovascular Interventions for Chronic Limb threatening ischemia (CLTI)

By Zia Ur REHMAN, Hafsa Shaikh, Asma Haque, Akhyar Nasir,

Objective: To determine the indications, lesion types, technical success, complications, and limb salvage rate in patients undergoing lower limb angio...


Iatrogenic Abdominal Vascular Injuries – A Case Series

By Zia Ur Rehman, Syeda Kanza Shabnum, Afsheen Ilyas,

Objective: To evaluate the pattern, patient related factors, and surgical outcomes of iatrogenic abdominal vascular injuries (IAVIs) managed at a tert...


Anaesthesia Facility Readiness in Pakistan: A Scoping Review of AFAT-Based Assessments in Punjab and Sindh

By Samie Asghar Dogar, Ausaf Khan, Muhammad Sohaib, Muhammad Hayat, Waleed Bin Ghaffar, Asad Latif,

This scoping review aimed to map and synthesise the available AFAT-based evidence on anaesthesia facility readiness in Pakistan using the World Federa...


Unpacking Enteric Fever in Pakistan: Insights into Clinical Patterns and Financial Burdens

By Maria Khan, SABA KHAN, Shifa Basharat, Zufishan Batool,

Typhoid fever (TF) and para-typhoid fever (PTF), generally referred to as enteric fever (EF), are acute febrile illnesses that are frequent and cause ...


Placental Changes in Pregnancies with Maternal Hyperglycaemia: A Case-Control Study

By Hira Ahmed, Hina Jabeen, Aisha Abdul Haq, Uzma Hameed, Soofia Nigar, Mahrukh Kamran,

Placental development and function are impacted by maternal hyperglycemia. This case-control study examined placental morphology in hyperglycemic and ...


Evaluation of Labour Care Guide Implementation and Documentation Gaps: A Clinical Audit in the OBGYN Department

By Farnaz Zahoor, SAMINA Aliya SABIR, Sana Afridi, Aliya Khan,

Objective: To ensure healthcare providers adhere to the guidelines outlined in the WHO Labour Care Guide (LCG) and identify gaps, errors or deviation...


Efficacy of Bone Marrow Aspirate versus Trephine Biopsy: A Comparative Analysis of Diagnostic Utilities at a Tertiary Haematopathology Centre

By Asim Qureshi, Ola Al Adawi, Hannia Qureshi, Sara Al Busaidi, Mohamed Boulassel, Murtadha Al Khabori,

This study compared the diagnostic utility of bone marrow aspirate (BMA) and bone marrow biopsy (BMB) in the evaluation of haematological disorders. A...


Outcomes of Cortical Mastoidectomy with Tympanoplasty in Patients with Mucosal Chronic Otitis Media

By Hamad Ur Rehman, FAHAD HASNAIN, Bakhteen Ullah, Aftab Ahmad, Muhammad Tariq, Halla Saboor,

Objective: To evaluate the outcomes of cortical mastoidectomy combined with tympanoplasty in patients with inactive mucosal chronic otitis media (COM)...


Utility of Team-Based Learning as A Curriculum Integration Tool

By Farhat Fatima,

Team-based learning was selected to serve as an engaging, as well as resource-efficient, teaching and learning strategy to achieve curriculum integrat...


Prostate Cancer Imaging using Tc 99m PSMA: A Practical Approach Toward Equitable Advanced Imaging in Resources Constrained Countries

By Muhammad Numair Younis, Abubaker Shahid,

Prostate malignancy is among the most frequently occurring malignancies of men. In addition to established techniques including ultrasonography, imagi...


N-Acetylcysteine SNAP Protocol: An Emerging Need in Pakistan

By Zofishan Anwar,

Acetaminophen poisoning remains a significant global health concern due to its widespread over-the-counter availability. N-acetylcysteine (NAC) is the...


Pancreatic Cancer Burden in Pakistan, A National Level Systematic Review and Meta-Analysis

By Yumnah Babar, Musu Li, Juncheng Dai, Honggang Yi,

Pakistan faces a hidden burden of pancreatic cancer, which although less common, is highly lethal. This study quantifies pancreatic cancer burden by s...


Postoperative Infection after Laparoscopic Cholecystectomy: Benchmarking Machine-learning Models in a Real-world Cohort

By Hongwei Zhao, Jianzhe Wang, Qi Chen, Hang Yang, Guohua Fan,

Objective: To benchmark machine-learning (ML) models for predicting postoperative infection after laparoscopic cholecystectomy (LC) in a real-world co...


Neonatal Septicaemia: Bacterial Isolates and their Antibiotic Susceptibility Profile

By Dr Shahla Tariq, Dr Sehrish Masood, Komal Khadim Hussain,

Objectives: To determine the frequency, etiological agents and patterns of antibiotic resistance in neonatal sepsis in a tertiary care Neonatal Intens...


Rethinking Transfusion Strategies in CABG: Acute Normovolemic Haemodilution versus Conventional Transfusion - A Systematic Review

By Diyan Muhammad, Taimur Asif Ali, Muhammad Anas Khan, Adil Khan, Sabir Shah, Izaz Iqbal,

Coronary artery bypass grafting (CABG) is among the most commonly performed cardiac surgical procedures worldwide and frequently requires perioperativ...


Efficacy of Reading Therapy on Anxiety Reduction among Patients with Schizophrenia

By Xiao Hu, Ye Li, Ce Zhang, Jin WANG,

Schizophrenia imposes heavy burdens on patients and their families. Herein, the effectiveness of reading therapy in alleviating anxiety among patients...