Epub Ahead of Print

Zinc Deficiency is Associated with Poor Glycemic Control

By Muhammad Farooq,

Objective: To assess the level of zinc in type 2 diabetes mellitus and its relation to glycemic control.
Study Design: Descriptive cross-secti...


The Relationship between Liver Injury and Serum Levels of C-Reactive Protein and Procalcitonin in Patients with Acute Pancreatitis

By Hongtao Mao, Xiujiang Li, Yuanping Cao, Zhenyu Liu, Haiming Chen,

Acute pancreatitis (AP) can cause damage to multiple organs in the whole body, and the liver is one of the most frequently affected by AP. Ninety-s...


Self and Peer Assessment of Teachers\' Attitude towards Teaching

By Ambreen Ansar, Robina Mushtaq Rizvi, Afsa Hussain, Aneela Nawaz, Abeera Zafar, Ammara Fayyaz,

Objective: To appraise the attitude of the teachers towards teaching and the factors affecting their attitudes, and compare self-assessed attitudes...


MRI Findings of Borderline Retroperitoneal Serous Cystadenocarcinoma: A Rare Entity

By Curcan Erbay, Elif Karadeli, Alper Parlakgumus,

Retroperitoneal serous cystadenocarcinoma is an extremely uncommon lesion. Here, we present MR imaging findings of a 40-year-old woman who was admi...


Combined Effect of Aerobic and Resistance Interval Training on Ejection Fraction in Myocardial Infarction-Randomised Control Trial

By Hania Farheen, Zara Khalid, Muhammad Iqbal Tariq, Tahira Sadiq, Imran Amjad, Tahir Ramzan,

This study was conducted to determine whether combination of aerobic and resistance interval training had superior effects than aerobic interval tr...


Pediatric Malignant Mediastinal Masses

By Rahat-ul-ain Kashif, Mahwish Faizan, Saadia Anwar,

Objective: To describe the clinical spectrum and outcome-associated variables of pediatric malignant mediastinal masses in a resource-limited setti...


Less Invasive Surfactant Administration in Preterm Infants with Respiratory Distress Syndrome

By Alia Halim, Haider Shirazi, Sadia Riaz, Syeda Shireen, Wahid Ali,

Objective: To compare the need of mechanical ventilation between LISA (less invasive surfactant administration) method and conventional INSURE meth...


Understanding Constipation: A Cross-sectional Study from a Developing Country Setting

By Minaz Mawani, Abdul Azeem, Sakina Gheewala, Nazish Butt, Shahab Abid,

A cross-sectional study was conducted in the Gastroenterology Clinics of The Aga Khan Hospital and Jinnah Postgraduate Medical Centre in Karachi. A...


Stress Response to Propofol versus Isoflurane Anesthesia in Patients Undergoing Gastric Surgery

By Yan Wu, Le Zhang, Gang Yin, Yishu Liu, Li Chen,

Objective: To compare the effects of propofol and isoflurane anesthesia on cortisol, insulin, and blood glucose levels surrounding operation period...


Surgical Outcomes of Idiopathic Macular Epiretinal Membrane Peeling

By Uzma Haseeb, Aziz Ur Rehman, Abdul Fattah Memon, Muhammad Haseeb, Nasir Memon,

Objective: To evaluate the surgical outcomes of idiopathic macular epiretinal membrane (IERM) peeling in terms of visual acuity and macular thickne...


Giant Pelvic Adenoma Originating from Ectopic Prostatic Tissue

By Xiao-qing Lu, Hai-ping Hu, Zhi-cheng Cong, Jian-di Yu,

Ectopic prostatic tissue detected outside the genitourinary system has been rarely reported. A case with a giant pelvic adenoma that originated fro...


Effect of Ultrasound Debridement on Serum Inflammatory Factors and bFGF, EGF Expression in Wound Tissues

By Qiuping Zou, Weiping Wang, Qinghua Li, Jiean Liu, Tianming Xu, Xinmin Zhao,

Objective: To determine the effect of ultrasonic debridement on serum inflammatory factors of procalcitonin (PCT), high-sensitivity C-reactive prot...


Coincidence of Dental Midline with Facial Midline in a Sample of Pakistani Population

By Mehwish Khan, Syed Murtaza Raza Kazmi,

Objective: To determine the frequency of coincidence of facial and dental midlines in a sample of Pakistani subjects.
Study Design: Cross-secti...


Impaction of Phytobezoar at Meckel\'s Diveticulum: A Rare Case of Small Bowel Obstruction

By Mohammad Masood Ur Rauf Hiraj Khan, Junaid Zia Hashmi, Naeem Lateef, Moazam Mumtaz, Farah Saleem,

Small bowel obstruction secondary to phytobezoars is a rare presentation in surgery. These are masses of undigested food and vegetables, which obst...


Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria

By Juan Wang, Yiding Zhao, Xiaoning Yan,

Objective: To determine the effects of desloratadine citrate disodium on serum immunological function indices (IgE, C3 and C4), inflammatory factor...


The Imaging Findings of Pulmonary Nocardiosis Mimicking Bronchiectasis: A Report of 2 Cases and Literature Review

By Lianmin Bao, Heping Lin, Ling Dong, Qing Zhang, Zongxiao Shangguan,

Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of imm...


All-Seeing-Access Sheath: A Novel Fluoroscopy-Free Placement Technique in Retrograde Intrarenal Surgery

By Musa Ekici, Berat Cem Ozgur, Aykut Bugra Senturk, Arzu Akdagli Ekici, Cemil Aydin, Mehmet Murat Baykam,

Objective: To evaluate the safety and effectiveness of fluoroscopy-free RIRS (Retrograde intrarenal surgery) method in urolithiasis.
Study Desi...


Effect of Magnesium Sulfate Combined with Phentolamine and Nifedipine for Gestational Hypertension and Serum Levels of LIF and Apelin

By Jie Wen, Xiaojing Li,

Objective: To investigate the effect of magnesium sulfate combined with phentolamine and nifedipine for the treatment of gestational hypertension a...


Inhaled Glucocorticoid with or without Tiotropium Bromide for Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

By Hailing Xu, Xiaoxia Lu,

Objective: To compare the efficacy of inhaled glucocorticoid with or without tiotropium bromide in the treatment of patients with asthma-chronic ob...


Expression of Snail and E-cadherin in Drug-resistant MCF-7/ADM Breast Cancer Cell Strains

By Fenglin Cai, Hualin Xiao, Yuting Sun, Dongfeng Wang, Jinhai Tang, Jinhai Tang,

Objective: To investigate the expression of zinc finger transcription factors-Snail and E-cadherin in adriamycin-resistant human breast cancer MCF-...


Differential Expression of Placental Growth Factor, Transforming Growth Factor-b and Soluble Endoglin in Peripheral Mononuclear Cells in Preeclampsia

By Zaima Ali, Saba Khaliq, Saima Zaki, Hafiz Usman Ahmad, Khalid Pervaiz Lone,

Objective: To measure the peripheral blood mononuclear cells (PBMCs) mRNA expression of placental growth factor (PlGF), Transforming growth factor ...


Comparison of Outcomes between Fractional-Flow-Reserve- and Angiography-Directed Intervention in Non-ST Elevation Acute Coronary Syndrome

By Yang Jianjun, Pang Xiaohua, Tu Xuemei, Huang Gang, Wang Hailong,

Among the sick patients suffering from non-ST segment elevation acute coronary syndrome (NSTEACS), the accuracy of fractional flow reserve (FFR)-di...


Effects of Liraglutide Combined with Insulin on Oxidative Stress and Serum MCP-1 and NF-kB Levels in Type 2 Diabetes

By Xia Liu, Jinwen Huang, Jiawei Li, Qinghua Mao, Jirui He,

Objective: To investigate the effects of liraglutide combined with insulin on oxidative stress and expression levels of serum monocyte chemoattract...


Oxidizing Effect of Ozonated-Water Maintains Microbial Balance in the Oral Ecosystem

By Fathilah Abdul Razak, Md. Yusoff Musa, Husham Amra Mahmod Abusin, Nosizana Mohd. Salleh,

Application of ozone is recommended for sterilisation in dental procedures. This study explored the antimicrobial effect of 0.1 ppm ozonated-water ...


Hypohydrotic Ectodermal Dysplasia in an Indian Family

By Anish A Gupta, Swati S Gotmare, Megha Jain, Treville Pereira, Pooja Khare,

Hereditary ectodermal dysplasia (HED) is a rare genetic disorder chiefly affecting ectodermally derived structures including hair, nails, sweat gla...


Sequential Optic Neuritis: A Neuromyelitis Optica Spectrum Disorder

By Mehtab Alam, Mian Ayaz Ul Haq, Asif Iqbal, Kaleem Ullah, Danish Nabi,

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune relapsing demyelinating disorder which often leads to severe disability typically t...


Montelukast and Budesonide for Children Cough Variant Asthma

By Wu Sun, Hai-yan Liu,

Objective: To determine the effects of combined treatment of montelukast and budesonide on young children with cough variant asthma, and their seru...


Chryseobacterium Indologenes as a Novel Cause of Bacteremia in Pediatric Patients: A First Reported Case and Literature Review

By Irfan Ali Mirza, Ayesha Khalid, Fatima Hameed, Anam Imtiaz, Ambar Ashfaq, Anam Tariq,

Chryseobacterium indologenes is a rare human pathogen. It is an emerging species, least frequently reported from pediatric age group and known to c...


Laparoscopic Surgery Combined with GnRH Agonist in Endometriosis

By Yu Yang, Weidong Zhu, Shuqiu Chen, Guangyuan Zhang, Ming Chen,

Objective: To determine the efficacy of laparoscopic surgery combined with GnRH agonist (GnRH-a) in treating infertile patients with endometriosis ...


Impact of Prostate Specific Antigen Level on Oncological Outcomes after Open Radical Prostatectomy

By Mustafa Sungur, Selahattin Caliskan,

Objective: To compare the impact of prostate specific antigen (PSA) on oncological outcomes in the patients with 4-10 and 10.01-20 ng/ml PSA level....


Traditional versus Percutaneous Transforaminal Endoforaminal Discectomy Effect on the Nervous System Function and Serum LEK, GFAP and PGE-2 in Patients with Senile Lumbar Spinal Stenosis

By Hejun Chen, Junlian Xue, Xinjiang Wu,

Objective: To compare the influence of percutaneous transforaminal endoscopic discectomy (PTED) and traditional operation on the nervous system fun...


Epidemiology and Treatment Outcomes of Sinonasal Tumors: A Single Institute\'s Experience in Pakistan

By Wajiha Anjum, Rab Nawaz Maken, Hasan Nisar, Ismat Fatima, Misbah Masood, Abu Baker Shahid,

Objective: To find the epidemiology and risk factors of sinonasal tumors and treatment outcomes in squamous cell carcinoma.
Study Design: An ob...


Differences of HBME-1 Expression in Thyroid Follicular Adenoma and Follicular Thyroid Carcinoma by Ultrasound-Guided Fine-Needle Aspiration Biopsy

By Junsong Wang, Li Xu, Xiaosen Xu, Xin Wang,

Objective: To investigate the differences in human bone marrow endothelial cell marker 1 (HBME-1) expression in thyroid follicular adenoma (FA) and...


Diffusion-Weighted Magnetic Resonance Imaging in Assessment of Primary Liver Cancer after HIFU Treatment

By Sheng Li, Sili Shi, Aiping Li, Huihui Liu, Lili Cai,

Objective: To determine the feasibility and role of diffusion-weighted magnetic resonance imaging (DWI) in the assessment of high-intensity focused...


Effect of Astragalus Polysaccharide on the Expression of VEGF and EGFR in Mice with Lewis Transplantable Lung Cancer

By Lichun Zhao, Yute Zhong, Jie Liang, Hongwei Gao, Nong Tang,

The aim of this study was to determine the effect of Astragalus polysaccharide (APS) on the expression of vascular endothelial growth factor (VEGF)...


Comparative Effects of Monosialoganglioside versus Citicoline on Apoptotic Factor, Neurological Function and Oxidative Stress in Newborns with Hypoxic-Ischemic Encephalopathy

By Shi-peng Liang, Qian Chen, Yi-bing Cheng, Ying-ying Xue, Hai-jun Wang,

Objective: To determine the comparative effect of monosialoganglioside versus citicoline on the content changes of serum apoptotic factors (PDCD5, ...


Conventional versus Minimally Invasive Vein Harvesting: A Clinical Audit of Wound Dehiscence Complications

By See Woan Shiang, Simon Jerome Vendargon, Syed Rasul Bin Ghouse Syed Hamid,

Objective: : To determine the wound complications post coronary artery bypass graft surgery (CABG) by conventional vein harvest technique (CVH) and...


A Novel Complication Following Retrograde Intrarenal Surgery: Retroperitoneal Hematoma

By Berat Cem Ozgur, Musa Ekici,

Retrograde intrarenal surgery (RIRS) is an efficient method for kidney stones with low complication rates. Reported here is an unusual complication...


Detection Rate of Thyroid Papillary Micro-carcinoma in Multinodular Goiter Surgery

By Bahri Ozer, Mustafa Sit, Gulali Aktas, Fatih Keyif, Ferdi Bolat, Hayri Erkol,

Objective: To determine the frequency of papillary thyroid micro-carcinoma (PTMC) in multinodular goiter (MNG) surgery, as well as in opposite thyr...


Small-Dose Ropivacaine Hydrochloride with Fentanyl versus Large-Dose of Ropivacaine Hydrochloride for Cesarean Section

By Jinwen Huang, Xia Liu, Shaoli Ding, Lei Zhu, Wenjun Yan,

Objective: To compare the effect of small-dose ropivacaine hydrochloride combined with fentanyl versus large-dose of ropivacaine hydrochloride for ...


Clinical and Demographic Features of 76 Children with Autism Spectrum Disorders at a Centre in Pakistan

By Ghazal Nadeem, Aleena Bibi, Bushra Suhaib, Suhaib Ahmed, Salman Ali,

In this cross-sectional study, 76 consecutive children with autism spectrum disorder (ASD) were studied for the clinical and demographic parameters...


Entecavir and Low Genetic Barrier Antiviral Agents for Hepatocellular Carcinoma in Hepatitis B Viral Cirrhosis: Propensity Score Matching

By Tao Li, Yundong Qu, Yan Wang, Chunlei Lin, Baohua Yang, Lei Wang,

Objective: To compare the reduction of hepatocellular carcinoma (HCC) risk between long-term treatment of entecavir and low genetic barrier antivir...


Myocardial Ischemia Presenting with Hiccups

By Shi-min Yuan,

Myocardial infarction/ischemia can be an underlying etiology and a major causative risk factor of cardiovascular hiccups. The objective of this sys...


Developing an Assessment-of-Clinical-Exodontia-Skills (ACES) Rating Scale for Undergraduate Dental Students

By Omer Sefvan Janjua, Abid Ashar, Tanzeela Khalid,

Objective: To develop assessment-of-clinical-exodontia-skills (ACES) rating scale for formative and summative assessment of undergraduate dental st...


Prenatal Diagnosis of b-thalassemia with Cell-free Fetal DNA in Maternal Plasma

By Lijian Zhao, Xuxia Liang, Haini Huang, Huihua Lan, Xin Wu, Chenhong Wang,

The aim of this study was to explore the feasibility of non-invasive prenatal genetic diagnosis of b-thalassemia with small fragments of cell-free ...


Need of Physical and Chemical Restraints: Experiences at Inpatient Psychiatric Ward in a Tertiary Care Hospital in Karachi, Pakistan

By Humera Saeed, M. Shameel Khan, Syeda Maheen Batool, Asma Akbar Ladak, Nadia Karim, Rabeeka Aftab,

In psychiatry, agitated / aggressive patients are often treated with de-escalation techniques. If this does not work, physical or chemical restrain...


Efficacy of Subconjunctival Injection of Bevacizumab in Regressing Corneal Neovascularisation

By Syed Shujaat Ali Shah,

Objective: To determine the efficacy of subconjunctival injection of bevacizumab in regressing corneal neovascularisation.
Study Design: Case s...


Rare Complication of the Hydrocephalus Case: Anal Extrusion of a Ventriculoperitoneal Shunt

By Omer Furkan Turkis, Ali Karadag, Erik H. Middlebrooks, Mehmet Senoglu,

Ventriculoperitoneal shunt (VPS) placement is an effective and most frequently used surgical method in the treatment of hydrocephalus, but the mech...


Frequency of Asthma and Atopic Diseases in Inflammatory Bowel Disease and Celiac Disease

By Fatma Yavuzyilmaz, Sebnem Ozdogan, Nafiye Urganci, Merve Kesim Usta,

Objective: To compare the frequency of asthma and allergic diseases in patients with inflammatory bowel disease and Celiac disease using internatio...


Retinal Ganglion Cell Complex Changes after Intravitreal Bevacizumab for Diabetic Macular Edema

By Muhammad Shaheer, Arooj Amjad, Zubair Saleem,

Objective: To measure the changes in ganglion cell complex as measured on optical coherence tomography (OCT) after intravitreal injection of bevaci...


Anterograde Reconstruction of Severe Bi-Canalicular Obstruction with Autogenous Saphenous Vein Graft: A Novel Surgical Technique

By Teyyeb Azeem Janjua, Bushra Akbar,

Severe lacrimal canalicular obstruction mandates a bypass surgery of conjunctivo dacryocystorhinostomy with Lester Jones tube or alternatively retr...


Comparing the Efficacy of Oral Chloroquine versus Oral Tetracycline in the Treatment of Cutaneous Leishmaniasis

By Fahmida Malik, Malik Muhammad Hanif, Ghulam Mustafa,

Objective: To compare the efficacy of oral chloroquine versus oral tetracycline in the treatment of cutaneous leishmaniasis (CL).
Study Desig...


Management of Leakage into the Abdomen due to the Involvement of Jejunum in the Incision Line

By Seracettin Egin,

Here, we present the management of a patient, developing severe peritonitis due to laceration of the jejunum, involving sutures applied to facial l...


Bosniak Classification and other Variables in the Prediction of Renal Cystic Masses

By Bugra Keseroglu, Berat Cem Ozgur, Sedat Tastemur, Lokman Irkilata, Ömer Gökhan Doluoglu, Cem Nedim Yücetürk,

Objective: To evaluate the variables of cystic renal lesions to predict the renal tumors.
Study Design: An observational study.
Place and Du...


Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm

By Chaohai Shi, Quan Chen,

Objective: To compare the clinical efficacy of unibody bifurcated endovascular stent-graft repair versus conventional open surgery for abdominal ao...


Efficacy of Catheter-directed Thrombolysis on Post-burn Deep Venous Thrombosis of Lower Extremity

By Guozheng Gao, Shugang Zhu, Zhen Xie, Jiasen Wang, Baohong Yao,

Objective: To observe the clinical effect of catheter-directed thrombolysis on deep venous thrombosis (DVT) of lower extremity after burn.
Stud...


Distribution of HLA-B*27 Subtypes in Patients with Ankylosing Spondylitis in Local Population

By Noor Afshan Lodhi, Muhammad Mukarram Bashir, Hamid Nawaz Tipu, Muhammad Hussain,

Objective: To compare the distribution of HLA-B*27 subtypes in healthy controls and in ankylosing spondylitis (AS) patients of different ethnic gro...


Effect of Irbesartan on Oxidative Stress and Serum Inflammatory Factors in Renal Tissues of Type 2 Diabetic Rats

By Xingang Zhao, Dongbin Yang, Weiwei Xu, Wen Xu, Zhengdong Guo,

Objective: To determine the effect of irbesartan on the activity of oxidative stress parameters of glutathione (GSH), superoxide enzyme (SOD) and m...


Influenza Virus Subtyping by Multiplex PCR during Winter Months of 2017-2018

By Misbah Noor, Saif Ullah Khan Niazi, Nadia Tayyab, Syed Adeel Gardezi, Eijaz Ghani, Muhammad Tahir Khadim,

Objective: To determine the frequency of infections caused by Influenza viruses, i.e. Influenza A (H1N1) pdm09, Influenza A (H3N2) and Influenza B ...


Myasthenia Gravis as a Cause of Failed Extubation Diagnosed by Diaphragmatic Ultrasound

By Priya Ramakrishnan, Shahla Siddiqui,

Myasthenia Gravis (MG) is an autoimmune disease of the neuromuscular junction which results in generalised weakness. Presentation varies and can of...


Comparison of Efficiency of TACE plus HIFU and TACE alone on Patients with Primary Liver Cancer

By Yuju Luo, Yu Jiang,

Objective: To compare efficiency of trans-arterial chemo-embolization (TACE) plus high intensity focused ultrasound (HIFU), and TACE alone on patie...


Comparison of Graft Survival between Fat Harvested from Abdomen and Medial Thigh for Facial Contour Deformity: A Randomised Control Trial

By Shohreh Ahmadi, Abdul Malik Mujahid, Husnain Khan, Farrukh Aslam Khalid, Muhammad Saleem, Muhammad Younas Mehrose,

Objective: To compare the graft survival between fat harvested from abdomen and medial thigh for facial contour deformity.
Study Design: Random...


Effect of Flap Fixation Technique in Modified Radical Mastectomy on Incidence of Postoperative Seroma Formation

By Erum Najeeb, Rakhshanda Rashid, Shaista Zaffar,

Objective: To determine the efficacy of flap fixation technique on formation of postoperative seroma after modified radical mastectomy.
Study D...


Effect of Phototherapy on Neutrophil VCS Parameters and White Blood Cells

By Nilgün Altuntas, Özlem Ceylan Dogan, Fatih Mehmet Kislal,

Objective: To investigate the effect of phototherapy (PT) on WBC parameters and neutrophil volume, conductivity and scatter (VCS) parameters.
S...


Effect of Prophylactic Ilioinguinal Neurectomy on Postoperative Groin Pain Following Lichenstein Hernioplasty

By Atif Sharif, Tasleem Akhtar, Mumtaz Akhtar, Irfan Malik, Muhammad Hanif, Naeem Zia,

Objective: To compare mean postoperative pain post-Lichenstein open hernioplasty with and without ilioinguinal neurectomy at six months.
Study ...