Epub Ahead of Print

Myocardial Ischemia Presenting with Hiccups

By Shi-Min Yuan,

Myocardial infarction/ischemia can be an underlying etiology and a major causative risk factor of cardiovascular hiccups. The objective of this sys...

Developing an Assessment-of-Clinical-Exodontia-Skills (ACES) Rating Scale for Undergraduate Dental Students

By Omer Sefvan Janjua, Abid Ashar, Tanzeela Khalid,

Objective: To develop assessment-of-clinical-exodontia-skills (ACES) rating scale for formative and summative assessment of undergraduate dental st...

Prenatal Diagnosis of β-thalassemia with Cell-free Fetal DNA in Maternal Plasma

By Lijian Zhao, Xuxia Liang, Haini Huang, Huihua Lan, Xin Wu, Chenhong Wang,

The aim of this study was to explore the feasibility of non-invasive prenatal genetic diagnosis of b-thalassemia with small fragments of cell-free ...

Need of Physical and Chemical Restraints: Experiences at Inpatient Psychiatric Ward in a Tertiary Care Hospital in Karachi, Pakistan

By Humera Saeed, M. Shameel Khan, Syeda Maheen Batool, Asma Akbar Ladak, Nadia Karim, Rabeeka Aftab,

In psychiatry, agitated / aggressive patients are often treated with de-escalation techniques. If this does not work, physical or chemical restrain...

Efficacy of Subconjunctival Injection of Bevacizumab in Regressing Corneal Neovascularisation

By Syed Shujaat Ali Shah,

Objective: To determine the efficacy of subconjunctival injection of bevacizumab in regressing corneal neovascularisation.
Study Design: Case s...

Anal Extrusion of a Ventriculoperitoneal Shunt

By Omer Furkan Turkis, Ali Karadag, Erik H. Middlebrooks, Mehmet Senoglu,

Ventriculoperitoneal shunt (VPS) placement is an effective and most frequently used surgical method in the treatment of hydrocephalus, but the mech...

Frequency of Asthma and Atopic Diseases in Inflammatory Bowel Disease and Celiac Disease

By Fatma Yavuzyilmaz, Sebnem Ozdogan, Nafiye Urganci, Merve Kesim Usta,

Objective: To compare the frequency of asthma and allergic diseases in patients with inflammatory bowel disease and Celiac disease using internatio...

Retinal Ganglion Cell Complex Changes after Intravitreal Bevacizumab for Diabetic Macular Edema

By Muhammad Shaheer, Arooj Amjad, Zubair Saleem,

Objective: To measure the changes in ganglion cell complex as measured on optical coherence tomography (OCT) after intravitreal injection of bevaci...

Anterograde Reconstruction of Severe Bi-Canalicular Obstruction with Autogenous Saphenous Vein Graft: A Novel Surgical Technique

By Teyyeb Azeem Janjua, Bushra Akbar,

Severe lacrimal canalicular obstruction mandates a bypass surgery of conjunctivo dacryocystorhinostomy with Lester Jones tube or alternatively retr...

Comparing the Efficacy of Oral Chloroquine versus Oral Tetracycline in the Treatment of Cutaneous Leishmaniasis

By Fahmida Malik, Malik Muhammad Hanif, Ghulam Mustafa,

Objective: To compare the efficacy of oral chloroquine versus oral tetracycline in the treatment of cutaneous leishmaniasis (CL).
Study Desig...

Management of Leakage into the Abdomen due to the Involvement of Jejunum in the Incision Line

By Seracettin Egin,

Here, we present the management of a patient, developing severe peritonitis due to laceration of the jejunum, involving sutures applied to facial l...

Bosniak Classification and other Variables in the Prediction of Renal Cystic Masses

By Bugra Keseroglu, Berat Cem Ozgur, Sedat Tastemur, Lokman Irkilata, Ömer Gökhan Doluoglu, Cem Nedim Yücetürk,

Objective: To evaluate the variables of cystic renal lesions to predict the renal tumors.
Study Design: An observational study.
Place and Du...

Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm

By Chaohai Shi, Quan Chen,

Objective: To compare the clinical efficacy of unibody bifurcated endovascular stent-graft repair versus conventional open surgery for abdominal ao...

Efficacy of Catheter-directed Thrombolysis on Post-burn Deep Venous Thrombosis of Lower Extremity

By Guozheng Gao, Shugang Zhu, Zhen Xie, Jiasen Wang, Baohong Yao,

Objective: To observe the clinical effect of catheter-directed thrombolysis on deep venous thrombosis (DVT) of lower extremity after burn.
Stud...

Distribution of HLA-B*27 Subtypes in Patients with Ankylosing Spondylitis in Local Population

By Noor Afshan Lodhi, Muhammad Mukarram Bashir, Hamid Nawaz Tipu, Muhammad Hussain,

Objective: To compare the distribution of HLA-B*27 subtypes in healthy controls and in ankylosing spondylitis (AS) patients of different ethnic gro...

Effect of Irbesartan on Oxidative Stress and Serum Inflammatory Factors in Renal Tissues of Type 2 Diabetic Rats

By Xingang Zhao, Dongbin Yang, Weiwei Xu, Wen Xu, Zhengdong Guo,

Objective: To determine the effect of irbesartan on the activity of oxidative stress parameters of glutathione (GSH), superoxide enzyme (SOD) and m...

Influenza Virus Subtyping by Multiplex PCR during Winter Months of 2017-2018

By Misbah Noor, Saif Ullah Khan Niazi, Nadia Tayyab, Syed Adeel Gardezi, Eijaz Ghani, Muhammad Tahir Khadim,

Objective: To determine the frequency of infections caused by Influenza viruses, i.e. Influenza A (H1N1) pdm09, Influenza A (H3N2) and Influenza B ...

Myasthenia Gravis as a Cause of Failed Extubation Diagnosed by Diaphragmatic Ultrasound

By Priya Ramakrishnan, Shahla Siddiqui,

Myasthenia Gravis (MG) is an autoimmune disease of the neuromuscular junction which results in generalised weakness. Presentation varies and can of...

Comparison of Efficiency of TACE plus HIFU and TACE alone on Patients with Primary Liver Cancer

By Yuju Luo, Yu Jiang,

Objective: To compare efficiency of trans-arterial chemo-embolization (TACE) plus high intensity focused ultrasound (HIFU), and TACE alone on patie...

Comparison of Graft Survival between Fat Harvested from Abdomen and Medial Thigh for Facial Contour Deformity: A Randomised Control Trial

By Shohreh Ahmadi, Abdul Malik Mujahid, Husnain Khan, Farrukh Aslam Khalid, Muhammad Saleem, Muhammad Younas Mehrose,

Objective: To compare the graft survival between fat harvested from abdomen and medial thigh for facial contour deformity.
Study Design: Random...

Effect of Flap Fixation Technique in Modified Radical Mastectomy on Incidence of Postoperative Seroma Formation

By Erum Najeeb, Rakhshanda Rashid, Shaista Zaffar,

Objective: To determine the efficacy of flap fixation technique on formation of postoperative seroma after modified radical mastectomy.
Study D...

Effect of Phototherapy on Neutrophil VCS Parameters and White Blood Cells

By Nilgün Altuntas, Özlem Ceylan Dogan, Fatih Mehmet Kislal,

Objective: To investigate the effect of phototherapy (PT) on WBC parameters and neutrophil volume, conductivity and scatter (VCS) parameters.
S...

Effect of Prophylactic Ilioinguinal Neurectomy on Postoperative Groin Pain Following Lichenstein Hernioplasty

By Atif Sharif, Tasleem Akhtar, Mumtaz Akhtar, Irfan Malik, Muhammad Hanif, Naeem Zia,

Objective: To compare mean postoperative pain post-Lichenstein open hernioplasty with and without ilioinguinal neurectomy at six months.
Study ...

Effect of Dexketoprofene Trometamol on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

By Aziz Ari, Bunyamin Gurbulak, Hasan Okmen, Cihad Tatar, Ufuk Oguz Idiz, Muhammed Zubeyr Ucuncu,

Objective: To evaluate the efficacy of dexketoprofene trometamol solution following the administration of contrast agent for Endoscopic Retrograde ...

Post-tuberculosis Pneumocytoma

By Mustafa Kupeli, Hakan Nomenoglu,

Pneumocytoma is a rare benign tumor of the lung that usually manifests as a solitary pulmonary nodule. A 69-year lady, who had history of tuberculo...

Spectrum of Biopsy Proven Extraocular Muscle Tumours of Non-Thyroid Origin

By Tayyab Afghani, Hassan Mansoor, Amna Manzoor Mughal, Mohammad Asif, Muhammad Asif, Naeem Raza Hamdani,

Objective: To describe different types of primary extraocular muscle (EOM) tumours based on the results of imaging studies, peroperative clinical p...

Application of Non-invasive Positive Pressure Ventilation Combined with PetCO2 Monitoring for Patients with Chronic Obstructive Pulmonary Disease Combined with Severe Respiratory Failure

By Fu-tao Cao, Yu Cui, Jia Mao, Fang Wan, Su Tu,

Objective: To investigate the role of PetCO2 monitoring in non-invasive positive pressure ventilation (NPPV) treatment for chronic obstructive pulm...

Scoping Review of Crimean-Congo Hemorrhagic Fever (CCHF) Literature and Implications of Future Research

By Braira Wahid, Saba Altaf, Nabiha Naeem, Nimra Ilyas, Muhammad Idrees,

Crimean-Congo hemorrhagic fever (CCHF) is one of the severe forms of high-fatality hemorrhagic fever transmitted by bite of infected ticks or body ...

Presternal Goiter

By Matheo Augusto Morandi Stumpf, Andre Scartezini Marques, Camila Gabriella Da Costa Belonci,

An enlarging thyroid normally extends into the mediastinum, resulting in a presternal or substernal goiter, depending on its migration anteriorly o...

Malakoplakia of the Urinary Bladder and Unilateral Ureter

By Saddaf Hina, Aisha Hasan, Nadeem Iqbal, Muhammad Usman Shabbir, Abdul Ahad Ehsan Sheikh,

Malakoplakia is an unusual acquired granulomatous disease that can affect many systems including urogenital tract. It presents a huge diagnostic ch...

Risk Factors for Infectious Complications in Patients Undergoing Retrograde Intrarenal Surgery

By Demirhan Orsan Demir, Omer Gokhan Doluoglu, Yildiray Yildiz, Selen Bozkurt, Ali Ayyildiz, Arif Demirbas,

Objective: To investigate the risk factors that may cause urinary tract infection (UTI) in patients applied with retrograde intrarenal surgery (RIR...

Inhibitory Effect of Semen Litchi Drug Serum on the Proliferation of Human Hepatoma HepG2 Cells and Expression of VEGF and MMP-9

By Lichun Zhao, Peiliang Yu, Tao Yang, Gailian Zhou, Nong Tang,

Objective: To investigate inhibitory effect of semen litchi drug serum on proliferation of human hepatoma HepG2 cells and its effect on the express...

Combination of Oral Tranexamic Acid with Topical 3% Tranexamic Acid versus Oral Tranexamic Acid with Topical 20% Azelaic Acid in the Treatment of Melasma

By Fahmida Malik, Malik Muhammad Hanif, Ghulam Mustafa,

Objective: To compare the effect of combination therapies of topical 3% tranexamic acid versus topical 20% azelaic acid each combined with oral tra...

Relationship between the Quality of Sleep and Psychiatric Morbidity among the Patients of Head and Neck Tumours

By Usama Bin Zubair, Humza Mumtaz, Rizwan Taj,

Objective: To assess the difference between mean sleep (PSQI) scores in the patients with head and neck tumours with and without the psychiatric mo...

A Single Institution\'s Experience with Cytogenetic and MRD Outcomes in Pediatric Acute Lymphoblastic Leukemia

By Asim Amjad, Rabia Muhammad Wali, Sadia Anjum, Raheela Mansoor,

Objective: To determine the frequency of cytogenetic type and its significance in the prognostic outcome of the pediatric patients in acute lymphob...

Outcomes of Left Main Percutaneous Coronary Intervention

By Muhammad Nasir Rahman, Bilal Hussain, Azmina Artani,

Objective: To study the outcomes of left main percutaneous coronary artery (LMCA) revascularisation.
Study Design: A descriptive study.
Plac...

Expression and Significance of miR-126 and miR-145 in Infertility due to Endometriosis

By Fang Cheng, Luyan Lu, Huixia Wang, Hong Cheng, Dawei Zhang,

The aim of this study was to determine the expression and significance of miR-126 and miR-145 in endometrial tissues in the mid-luteal phase of pat...

Accessibility to Healthcare and Risk of Polypharmacy on Chronically ill Patients

By Suleyman Ersoy, Velittin Selcuk Engin,

Objective: To investigate the rates of polypharmacy (PP) and its relations with accessibility to health services in chronic patients in a primary c...

Metastatic Carcinoma of Endometrium from Primary Ovarian Serous Carcinoma Mimicking a Primary Uterine Tumour

By Mengfei Xu, Feng Zhou, Lili Huang,

A 44-year female was admitted to the hospital, complaining of vaginal bleeding. Ultrasound imaging revealed two masses in the pelvic cavity, measur...

Effectiveness of Direct Observation of Procedural Skills (DOPS) in Postgraduate Training in Urology at Institute of Kidney Diseases, Peshawar

By Liaqat Ali, Saima Ali, Nasir Orakzai, Naila Ali,

Objective: To determine the effectiveness of direct observation of procedural skills (DOPS) in the assessment and improving operative skills of pos...

Effect of Dexamethasone on TGF-b1/Smad3 Signalling Pathway in Airway Remodelling Model of Asthmatic Rats

By Yan Feng, Chang Yang, Wen Yan, Tao Jiang,

Objective: To determine the effect of dexamethasone on regulating the TGF-b1/Smad3 signalling pathway in airway remodelling model of asthmatic rats...

Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1b, IL-6 and TNF-a in Spinal Cord of Rats with Bone Cancer Pain

By Jun Chen, Xiufeng Cong, Xiuzhu Zhan, Zheng Zhou, Wei Zheng,

Objective: To investigate the effects of parecoxib on pain threshold and inflammatory factors interleukin-1b (IL-1b), interleukin-6 (IL-6) and tumo...

Evaluation of Thin Layer Agar 7H11 for Direct Susceptibility Testing of Mycobacterium Tuberculosis Complex against Second Line Anti Tuberculosis Drugs on Smear Positive Specimens

By Ashfaq Hussain, Gohar Zaman, Luqman Satti, Aamer Ikram, Adeel Hussain Gardezi, Muhammad Tahir Khadim,

Objective: To evaluate performance of thin layer agar (TLA) 7H11 method for detection of ofloxacin (OFX) and kanamycin (KM) resistance in smear pos...

Cerebral Aneurysms due to Cardiac Myxoma

By Shi-Min Yuan,

Cerebral aneurysms due to cardiac myxoma has been sporadically reported; however, the clinical features of this entity has not been fully elucidate...

Is Adenotonsillar Size a Significant Factor on Voice in Children Undergoing Adenotonsillectomy?

By Suleyman Emre Karakurt, Mehmet Ali Cetin, Ali Riza Yamur, Aykut Ikinciogullari, Serdar Ensari, Haci Huseyin Dere,

Objective: To determine whether adenotonsillar size is a significant determinant of voice in children who have undergone adenotonsillectomy.
St...

Cost Analysis of Emergency Department Visits by Geriatric Patients Living in Nursing Homes

By Murat Seyit, Atakan Yilmaz, Duygu Aras Seyit, Mert Ozen,

Objective: To determine the cost analysis of emergency department (ED) visits by geriatric patients living in nursing homes.
Study Design: Cros...

Haemangioendothelioma of Oral Cavity: A Rare Entity with Unusual Location

By Patel Nikita Rajendrakumar, Jagtap Kiran Suresh, Anjali Wadhwa, Pravin Mukhi, Pranjal Anil Patel,

Hemangioendothelioma is a rare, locally aggressive vascular tumor, originating from soft tissue, bone, skin, and organs such as liver or lung and e...

Prenatal Ethanol-Induced Effect on Cell Count of Pars Distalis of Pituitary Gland in the Rat Pups

By Nadia Rashid, M. Yunus Khan,

Objective: To determine the effects of prenatal administration of ethanol on cell count in pars distalis of pituitary gland in the rat pups.
St...

Does MDR1 Analysis Predict Medical Therapy Modifications in Patients with Atrial Fibrillation?

By Ayhan Akoz, Kenan Ahmet Turkdogan, Bekir Dagli, Mucahit Kapci, Mucahit Avcil, Gokay Bozkurt, Ali Duman,

Objective: To evaluate the effects of multi-drug resistance gene (MDR1) gene factor which is significant in medicine-receptor relationship, on read...

Comparing Reinforcement Options for the Staple Line of Laparoscopic Sleeve Gastrectomy

By Mehmet Bayrak, Yasemin Altintas,

Objective: To compare three reinforcement options (suture, fibrin glue, and no reinforcement) for staple line reinforcement of patients undergoing ...

Predictors of Blood Culture Positivity in Pediatric Brucellosis

By Soner Sertan Kara, Yasemin Cayir,

Objective: To investigate the predictors of blood culture positivity in children with brucellosis.
Study Design: Descriptive study.
Place an...

A Novel Mutation in the Choroideremia Gene in a Turkish Family

By Mustafa Iftikhar, Yulia Wolfson, Simrat Sodhi, Bushra Usmani, Hendrik P. N. Scholl, Syed M.a. Shah,

Choroideremia is an X-linked recessive genetic disorder caused by mutations in the CHM gene. It is a rare retinal dystrophy that manifests as nycta...

Hirschsprung\'s Disease: A Rare Entity in Adults

By Tufail Ahmad, Misbah Riaz, Attaullah Khan, Mah Muneer Khan,

Hirschsprung\'s disease (HD), a classic disease of childhood, may rarely escape diagnosis and lead to unique presentations in adults. By definition...

SAPHO Syndrome in an Adult Male with Ulcerative Colitis

By Sana Sayeed, Areeba Imtiaz, Faiza Naz,

Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) syndrome refers to a rare entity expressed by a combination of dermatological and osteoarti...

Propofol Target-Controlled Infusion in Anesthesia Induction during Painless Gastroscopy

By Dong-ni Li, Guo-qing Zhao, Zhen-bo Su,

Objective: To investigate the feasibility of using the eyelash reflex as an indicator to calculate the individualised optimal target concentration ...

Treating Foot Injuries by Grafting Pedicled Distal Peroneal Artery Perforator Flaps

By Changqing Hu, Yong Lian, Xiao Fan, Zhiping Sun,

Treating mid- and forefoot wounds is challenging. We share our clinical experience and describe the treatment of fore- and midfoot wounds by grafti...

Diagnostic Accuracy of Doppler Ultrasonography in Predicting Presence of Esophageal Varices in Patients with Hepatitis-C Induced Cirrhosis

By Ali Mansoor, Rabia Shaukat, Aamer Nadeem Chaudhary, Gohar Jehan,

Objective: To determine the diagnostic accuracy of Doppler ultrasonography in predicting presence of esophageal varices in patients with hepatitis-...

Acute Necrotizing Encephalopathy

By Farida Jan, Sidra K. Jafri, Shahnaz H. Ibrahim,

Objective: To describe the clinical profile of pediatric patients with acute necrotizing encephalopathy (ANE).
Study Design: Case series.
Pl...

Application of New Biomedical Materials in Orthodontic Appliances

By Hafiz Taha Mahmood, Adeel Tahir Kamal, Bushra Nazeer Khan, Mubassar Fida,

This review article describes the application and characteristics of certain biomedical materials in orthodontic appliances. The elastic recoil of ...

Mahidol Scoring for Assessing Various Grades of b Thalassemia Intermedia

By Jovaria Mannan, Muhammad Naveed, Saher Gul Ahdi,

Objective: To determine the effectiveness of Mahidol Scoring for assessing various grades of b thalassemia intermedia.
Study Design: Cross-sect...

Genetic Association of Apolipoprotein A5-1131T>C Polymorphism with Traits of Metabolic Syndrome

By Uzma Zafar, Saba Khaliq, Khalid Pervaiz Lone,

Objective: To investigate the association of -1131T>C polymorphism of apolipoprotein A5 (APOA5) with metabolic syndrome and associated traits. <...

Comparison of Proximal Femoral Nail Antirotation and Dynamic Hip Screw Internal Fixation on Serum Markers in Elderly Patients with Intertrochanteric Fractures

By Bin Wang, Qingbai Liu, Yu Liu, Rui Jiang,

Objective: To compare effect of proximal femoral nail antirotation (PFNA) and dynamic hip screw (DHS) internal fixation on serum inflammatory media...

The Blunt Abdominal Trauma Bedside Ultrasonography Comparison with Trauma Severity Scores and Computerized Tomography

By Hizir Ufuk Akdemir, Fatih Caliskan, Celal Kati, Ahmet Baydin,

Objective: To investigate the accuracy of focussed assessment sonography for trauma (FAST) bedside ultrasonography application in patients with blu...

Comparison of the Efficacy of Nilotinib and Imatinib in the Treatment of Chronic Myeloid Leukemia

By Bang-shuo Zhang, Yong-ping Chen, Jing-long Lv, Yi Yang,

Objective: To compare the efficacy of nilotinib and imatinib in the treatment of chronic myeloid leukemia (CML).
Study Design: Analytical study...

Effect of Pterygium Morphology on Recurrence with Preoperative Subconjunctival Injection of Mitomycin-C in Primary Pterygium Surgery

By Faisal Aziz Khan, Shafaq Pervez Khan Niazi,

Objective: To investigate the effect of pterygium morphology on recurrence with preoperative subconjunctival injection of mitomycin-C in primary pt...

Effects of Somatostatin Combined with Pantoprazole on Serum C-Reactive Protein and Intercellular Adhesion Molecule-1 in Severe Acute Pancreatitis

By Jun Liu, Yan Liu, Lei Huang, Xiangang Xu, Jun Wang,

The objective of this study was to investigate effects of somatostatin combined with pantoprazole on serum C-reactive protein (CRP) and intercellul...

Growth Hormone and ACTH Deficiency in a Diabetic Adult

By Asif Ali Memon, Mehwish Gilani, Naveed Asif, Nida Basharat,

Adult growth hormone deficiency (AGHD) syndrome has a constellation of features, like impaired cognitive function, altered body composition, poor q...

A Case of Dynamic Evolution of Thyrotoxicosis on Follow-up

By Cong Qing Miao, De Chuan Lu, Jing Jing Liu, Hui Xu, Xin Long Meng,

A 55-year female patient presented with subacute thyroiditis (SAT) with a unique dynamic evolution, along with changes in the level of antithyroglo...

Coexistence of Papillary Thyroid Cancer and Primary Hyperparathyroidism: Report of Five Cases

By Hasan Calis, Nuraydin Ozlem, Serif Melih Karabeyoglu,

Coincidence of primary hyperparathyroidism and thyroid nodules is quite frequent. This is challenging for clinical diagnosis and treatment. We revi...

Primary Supraclavicular Cystic Lymphangioma in an Adult: A Rare Presentation

By Mansoor Tariq Azim, Syed Mukarram Hussain, Mohammad Awais Mughal,

Cervicothoracic cystic lymphangiomas are found commonly in children less than 2 years of age, but the same are rare in adults. These form as a resu...

An Adult Case of Thiamine-Sensitive Megaloblastic Anemia Syndrome Accidentally Diagnosed Myelodysplastic Syndrome

By Ali Kutlucan,

Thiamine-responsive megaloblastic anemia (TRMA) syndrome is a rare disease comprising a classic triad of megaloblastic anemia, diabetes mellitus, a...

Endothelial Cysts of Adrenal Gland

By Zafar Ali, Hina Tariq, Usama Rehman,

Adrenal endothelial cyst is a rare entity which has female predilection and usually presents with abdominal pain. Smaller cysts are mostly asymptom...

JC Virus Infection: A Clinical Conundrum

By Hajra Farooq, Saifullah Khan Niazi, Misbah Noor, Eijaz Ghani,

John Cunningham virus (JCV), a member of polyomaviridae family, has been described as a cause of the progressive multifocal leukoencephalopathy (PM...

Gastric Tuberculosis

By Naresh Kumar Seetlani, Khalid Imran, Qurat Ul Ain Hafeez, Asif Ali, Pyar Ali Fazil, Bareeha Shaukat Sultan, Sulhera Khan,

Gastric tuberculosis is a very rare disease posing a diagnostic challenge to physicians, pathologists and radiologists. It usually occurs in female...

Congenital Erythropoietic Porphyria: A Rare Case of Photosensitivity with Hemolytic Anaemia and Mental Retardation

By Nadia Shirazi, Payal Chauhan, Rashmi Jindal, Sohaib Ahmad,

Congenital erythropoietic porphyria, also called Günther\'s disease, is a very rare genetic autosomal recessive disease affecting less than 1 per ...

Ischemic Skin Necrosis in Hepatorenal Syndrome Patient Secondary to Terlipressin

By Raheel Ahmed, Abdul Haseeb,

Hepatorenal syndrome and variceal bleeding are two serious complications of chronic liver disease. Terlipressin is commonly used for reversal of th...

Adult-Onset Subacute Sclerosing Panencephalitis Presented with Neuropsychiatric Symptoms

By Abdulkerim Gokoglu, Hasan Tahsin Gozdas,

Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disease caused by persistent infection of the brain with the measles ...

Primary Extra-renal Wilms\' Tumor in Urinary Bladder: Rare Presentation of a Common Pediatric Malignancy

By Irfana Ishaq Sindhu, Haleema Saeed, Rabia Wali, Asma Mehreen,

In pediatric population, the most common solid malignant tumor of the kidney is Wilms\' tumor (WT). Incidence of Extra-Renal Wilms\' Tumor (ERWT) i...

Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis

By Jamal-uddin Mughal, Asif Jan Muhammad, Uzma Erum,

Ocular cicatricial pemphigoid (OCP) is a rare autoimmune disease with heterogenous clinical manifestations. The classical lesion involves ocular co...

Traboulsi Syndrome in Pakistan

By Tehmina Awais, Mehmood Ali, Saad Alam Khan,

Traboulsi syndrome is characterised by facial dysmorphism, abnormal spontaneous filtering blebs, ectopia lentis and multiple anterior segment abnor...

Shprintzen-Goldberg Syndrome: A Rare Disorder

By Attia Bari, Nadia Sadaqat, Nadia Nawaz, Iqbal Bano,

The Shprintzen-Goldberg syndrome (SGS) or velo-cardio-facial syndrome (VCFS) is an extremely rare disorder of connective tissue with a characterist...

Primary Pulmonary Hypertension Associated with Asymptomatic Methylmalonic Aciduria in a Child

By Fatma Zohra Chioukh, Kamel Monastiri,

Methylmalonic acidemia or aciduria (MMA) is an inborn error of metabolism that results in the accumulation of methylmalonic acid in blood with an i...

Primary Iliopsoas Abscess in a Neonate

By Muhammad Umar Nisar, Samer Sikander, Zenab Noorain, Mehr-un-nisa Shahid Baig, Nadeem Akhtar,

Iliopsoas abscess (IPA) is rare in children but exceptional in neonates. Fewer than 30 cases have been reported in literature. We present a case of...

A Rare Cause of Intractable Diarrhea of Infancy

By Salman Ali, Aroma Tariq, Maryam Ghuncha,

Intractable watery diarrhea presenting in the neonatal period is a relatively uncommon condition. Congenital disorders of malabsorption are among t...

A Neonate with Upper GI Bleeding

By Suneeta Khemani, Huma Huma, Mumtaz Malik, Faiqa Hassan,

Bleeding in the newborn is often a serious problem because of cardiovascular effects associated with a loss of blood and/or the damaging effects of...

A Child with Weight Loss and Alacrimation: Triple A Syndrome

By Qurat Ul Ain, Naveed Asif, Noreen Shahzad, Waqas Hanif Sheikh,

Triple A syndrome or Allgrove\'s syndrome is a rare autosomal recessive disorder usually manifested with three main clinical features, i.e. achalas...

A Child with Ambiguous Genitalia: An Atypical Presentation

By Waqas Hanif Sheikh, Naveed Asif, Muhammad Younas, Nida Basharat, Qurat-ul Ain, Noreen Noreen,

Lipoid congenital adrenal hyperplasia (LCAH) (OMIM No. 201710) is the most severe type of congenital adrenal hyperplasia (CAH). Its clinical presen...

Erotomania in Depressive Psychosis: Mood Incongruent Delusion in a Depressive Young Woman

By Usama Bin Zubair, Sawera Mansoor,

Erotomania is a delusional phenomenon in which patient believes that some celebrity is in love with her. It is associated with various psychiatric ...

Polyarthritis as the Initial Presentation of Hyper Eosinophilic Syndrome

By Lubna Nazir, Amir Riaz, Hamza Alam,

Hyper eosinophilic syndrome (HES) is a rare condition with a potential for morbidity and mortality, if left untreated. Therefore, it is important t...

Bladder Hernia, Bladder Stone and Contralateral Bowel Hernia: An Usual Combination

By Akif Erbin, Halil Lutfi Canat, Burak Ucpinar, Hayati Malcik,

We report and discuss a rare case of inguino-scrotal urinary bladder herniation (IBH) complicated with a big urinary bladder stone and contralatera...

Adrenal Myelolipoma with Adrenocortical Adenoma Presenting with Hypertension Only

By Fan Yang, Chenyu Sun, Shiyu Pang, Juanjuan Cai, Hao Lin, Wanlong Tan,

Here, we present a case of a 25-year-old Chinese female who was diagnosed with non-functional adrenocortical adenoma containing myelolipoma with hy...

Neoaorta Reconstruction Using Both Femoral Veins in a Patient with Secondary Aortoenteric Fistula

By Zia-ur Rehman,

In situ reconstruction using femoral veins is emerging as one of the acceptable options for aortic reconstruction in patients with aortoduodenal fi...

Detection and Management of Pregnancy in Rudimentary Horn of Uterus

By Rizwana Parveen,

Pregnancy in rudimentary horn is extremely rare and usually terminates in rupture during first and second trimester of pregnancy. Diagnosis of rudi...