Letter to the Editor     June 2020  

Mesenteric Hematoma: Challenges in Diagnosis and Management

By Kamal Kant Sahu1, Ajay Kumar Mishra1, Amos Lal1, Iryna Chastain1

Affiliations

  1. Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, United States of America


Sir,

Mesenteric hematoma (MH) is a rare but a fatal complication of antithrombotic therapy, if not managed properly. Through this letter, we discuss the important bedside clinical signs of intra-abdominal bleeding and management strategies.

Figure 1A: Ecchymosis extending from flank to the front of the lower abdomen, with approximate dimensions of 5×5 cm.

Figure 1B: CT abdomen transverse section showing large mesenteric hematoma (8×8×6 cm) with adjacent mesenteric fat stranding with a higher attenuation of 45-50 HU.

A 65-year old man with a past medical history of atrial fibrillation, on warfarin, presented for abdominal pain of three days' duration. Examination showed bluish discoloration of approximately 5x5 cm over his right flank (Figure 1A). Investigations showed large MH (Figure 1B), anaemia (Hb-7.2 gm/dL) and coagulopathy (INR-4.3). His warfarin was stopped. He was given 2 units of packed red blood cells (PRBCs) and 5 mg Vitamin K, after which his clinical condition improved without recurrence of symptoms or further fall in haemoglobin.

Bluish discolouration involving the flank and extending on to the front of the abdomen, above the hip, is classically known as Grey Turner's sign.1 It has been classically described in haemorrhagic pancreatitis resulting in a large retroperitoneal hematoma (RPH). In various prospective studies, this clinical sign is reported to be present in around ~1% of patients with acute pancreatitis.2-4 It is postulated to result from methaemalbumin (MHA), an albumin complex formed as a result of combination of albumin and heme, giving bluish-brown color to the skin when it leaks into the fascial plains. Similarly, Cullen’s and Fox’s signs are two other clinical signs (Table I).

RPH is a rare complication, with an incidence of 1.3% to 6.6% per year. Hypotension, altered mentation and death are expected sequelae in cases of massive RPH, if not addressed timely. Underlying comorbidities like bleeding diathesis, thrombocytopenia, and use of anticoagulation could be extremely devastating. In most cases, RPH needs a supportive medical management only which includes stopping inciting antithrombotic agent, transfusing blood products including use of reversal agents like Vitamin K, Kcentra, etc. Though FDA has approved targeted anti-reversal agents, namely, idarucizumab (dabigatran’s reversal agent), Andexanet (Factor Xa inhibitor’s reversal agent), they are still far from practical uses due to high cost and insurance-related obstacles. Hence, warfarin remains the widely considered anticoagulant given the universal availability of fresh frozen plasmas (FFPs), Vitamin K, etc.5,6 Very rarely, surgical ligation is required in case active bleeding vessel is recognised and patient remains hemodynamically instable despite best supportive care. Moreover, the role of interventional radiology-guided approach is increasingly being popular owing to its simplicity, less complications and outstanding outcome. Embolization can be either by local thrombus formation or by local polymer formation.

Once the patients are appropriately managed for bleeding episode, next few questions arise: How long should we wait to restart anticoagulation? Would direct oral anticoagulants (DOACs) be a better choice than warfarin? How to follow patients with RPH, and the role of imaging?

Available literature suggests that it is reasonable to restart anticoagulants after four to seven days of stoppage of bleeding.5 Till date, there is no study to compare warfarin vs. DOACs with regard to anticoagulation of choice during post-bleeding episode.

We aim to emphasise that the role of various imaging techniques and investigations should be an add-on to the clinical examination and not to replace them. Reporting of such cases will ensure to keep the zeal of bedside examination intact amongst the internists.

Table I: Table showing signs, mechanism of development, associated conditions and their clinical significance.

Signs

Location

First reported by

Mechanism of sign

Seen in

Grey Turner’s

Ecchymosis/discoloration of the flanks

British surgeon George Grey Turner

Enzymatic digestion

digested blood tracks subcutaneously around the abdomen from the inflamed pancreas

  • Acute pancreatitis,
  • Pancreatic hemorrhage,
  • Retroperitoneal hemorrhage,
  • Ruptured / ectopic pregnancy,
  • Spontaneous bleeding,
Aortic rupture

Cullen sign

Periumbilical ecchymosis

American gynecologist, Thomas Stephen Cullen

Results from blood tracking subcutaneously along the gastrohepatic and falciform ligament around the umbilicus

  • Same as above

Fox’s sign

Upper thigh along the inguinal ligament

American dermatologist, George Henry Fox

Blood extravasation along the fascial plain of psoas and

iliacus muscle beneath the inguinal ligament which then manifests as subcutaneous discoloration in the upper thigh

  • Same as above
  • Strangulated ileum,
  • Urethral instrumentation,
  • Reaction to subcutaneous injections,
  • Pulmonary infarction.

Bryant’s sign

Blue discoloration of the scrotum

John Henry Bryant

Extravasation of blood beneath intact penile or scrotal epithelium

  • Ruptured AAA
  • Retroperitoneal hematoma

Stabler’s sign

Bruising of the pubis and groin

Francis Edward Stabler

Extravasation of blood in subcutaneous plain in inguinal-pubic area

  • Adrenal hemorrhage
  • Retroperitoneal hemorrhage
  • Ruptured neuroblastoma

Seat Belt sign

Bleeding in the Subcutaneous plain along the diagonal strap

Garrett and Braunstein

Contusion usually sustained during motor vehicle accident

  • Motor vehicle injury

Fountain’s sign

Ultrasonographic sign in transverse color Doppler of scrotum

-

Hypervascularity of the scrotal sac wall gives an impression of Fountain in doppler study

  • Acute idiopathic scrotal edema (AISE)

CONFLICT OF INTEREST:
Authors declared that none of them had any conflict of interest.

AUTHORS’ CONTRIBUTION:
KKS, AKM, AL, IC: Case management, review of literature, manuscript writing, table making and proof reading.
KKS, AKM: Photography.

REFERENCES

  1. Rao AG, Swathi T, Farheen SS, Kolli A, Hari S, Reddy UD, et al. Desmoid tumor of rectus abdominis presenting with grey-turner's and cullen's sign: A report of a rare case. Indian J Dermatol 2017; 62(3):318-20.
  2. Sahu KK, Mishra AK, Zhang P. Femoral neuropathy: A rare presentation of retroperitoneal hematoma with review of literature. Indian J Hematol Blood Transfus 2019; 01126-5.
  3. Wright WF. Cullen sign and grey turner sign revisited. J Am Osteopath Assoc 2016; 116(6):398-401.
  4. Sahu KK, Maradana S, Mishra A, Chastain I. A spontaneous rectus sheath hematoma. Intern Emerg Med 2018; 13(8): 1341-3.
  5. Colantino A, Jaffer AK, Brotman DJ. Resuming anticoagulation after hemorrhage: A practical approach. Cleve Clin J Med 2015; 82(4):245-56.
  6. Sahu KK, Mishra AK, Lal A, George SV. Retroperitoneal and rectus sheath hematomas: Challenges in diagnosis and management. Am J Surg 2019; S0002-9610(19)30764-0.