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Volume 32, 12 Issues, 2022

Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Important Announcement for Authors

"As a large number of case reports are awaiting publication, JCPSP has decided to stop acknowledging Case Reports for a certain period of time until the backlog is cleared. Therefore, case reports are regretted from processing".

Latest Articles
Volume 32 | Issue 12 | December 2022
Anxiety Disorders: Flying Under the Radar of Mental Health

By Saniya Raghib Sabzwari


Predicting the Severity of Coronary Artery Disease: Can the Leukocyte Glucose Index be Used?

By Oguz Kilic, Ipek Buber, Fatih Kahraman

ABSTRACT Objective: To investigate the usability of leuko-glycemic index (LGI) at chronic coronary syndromes (CCS) class 1 for determining the extent and severity of coronary artery disease (CAD). Study Design: An observational study. Place and Duration of Study: Department of Cardiology, Universit...

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Assessment of Relationship between Hemodynamic Changes and Anxiety in Patients During Lower Third Molar Surgery

By Ozgun Yildirim, Kadir Turkmenoglu, Nur Mollaoglu

ABSTRACT Objective: To investigate the relationship between anxiety and hemodynamic changes in patients who have undergone impacted third molar surgery under local anaesthesia. Study Design: Observational clinical study. Place and Duration of study: Department of Oral and Maxillofacial Surgery, Facu...

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Is there a Correlation between Hepatic Venous Indices and Main Pulmonary Artery Diameter?

By Taha Yasin Arslan, Erdogan Bulbul, Bahar Yanik, Gulen Demirpolat, Emrah Akay

ABSTRACT Objective: To search whether there is a correlation between middle hepatic venous indices (HVIs) obtained by pulsed waved doppler ultrasonography (PW-DUS) and the main pulmonary artery (mPA) diameter, calculated by computed tomography (CT). Study Design: A descriptive cross-sectional study....

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Two-point Fixation for Biological Mesh in Laparoscopic Inguinal Hernia Repair

By Guozhong Liu, Yiping Chen, Yuhai Hu, Jianbin Zhang, Shangeng Weng

ABSTRACT Objective: To evaluate the clinical outcomes and safety of two-point fixation for biological mesh in laparoscopic totally extraperitoneal (TEP) inguinal hernia repair. Study Design: Case series. Place and Duration of Study: The first Affiliated Hospital of Fujian Medical University Hospital...


Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever

By Oguz Gundogdu, Onur Avci

ABSTRACT Objective: To evaluate the power of the systemic immune-inflammation index in the prediction of mortality in severe Crimean-Congo hemorrhagic fever patients. Study Design: Observational study. Place and Duration of Study: Department of Anaesthesiology and Reanimation, Sivas Cumhuriyet Unive...

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Does the Implementation of Flipped Classroom Model Improve the Learning Outcomes of Medical College Students? A Single Centre Analysis

By Maria Hasan Baloch, Sana Shahid, Saima Saeed, Areeba Nasir, Sumreena Mansoor

ABSTRACT Objective: To assess the perspectives of the first year and second year MBBS students of College, regarding the effectiveness of flipped classroom learning as compared to the traditional mode of teaching. Study Design: A descriptive study. Place and Duration of Study: Shifa College of Medic...

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Relationship of Gamma-glutamyl Transferase Levels at Diagnosis with Clinicopathological Features in idiopathic IgA Nephropathy

By Sinan Kazan, Onur Tunca, Elif Dizen Kazan, Cigdem Ozdemir, Sumeyra Koyuncu, Hulya Akgun

ABSTRACT Objective: To compare clinicopathologic features of idiopathic IgA nephropathy in terms of serum gamma-glutamyl transferase (GGT) levels. Study Design: Cross-sectional study. Place and Duration of Study: Department of Nephrology and Department of Pathology, Afyonkarahisar Health Sciences Un...

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Transforaminal Endoscopic Lumbar Discectomy versus Open Decompression Discectomy for Lumbar Disc Herniation

By Jingxuan He, Peng Wang, Xiaofeng Xia, Jin Tang

ABSTRACT Objective: To compare the efficacy of transforaminal endoscopic lumbar discectomy (TELD) and open decompression discectomy (ODD) in the treatment of single-segment L4/5disc herniation. Study Design: Descriptive study. Place and Duration of Study: Department of Orthopedics, General Hospital ...

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Could Birth Weight to Placental Weight Ratio Predict Postpartum Haemorrhage and Neonatal Intensive Care Unit Admission?

By Burak Elmas, Deniz Simsek, Burcu Dincgez, Gokay Ozceltik, Canan Urun, Hasan Yilmaz Akin

ABSTRACT Objective: To evaluate the usability of the ratio of birth weight to placental weight [fetoplacental ratio (FPR)] in predicting postpartum haemorrhage (PPH) and neonatal intensive care unit (NICU) admission. Study Design: Prospective observational study. Place and Duration of Study: Bursa ...

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Establishment and Validation of a Novel Nomogram for Predicting Distant Metastasis in Patients with Invasive Lung Adenocarcinoma

By Zhanyue Pang, Haibo Liu, Zhitao Chen, Liangming Zhu

Objective: To establish and verify a nomogram for predicting distant metastasis in invasive lung adenocarcinoma (IAC). Study Design: Observational study. Place and Duration of Study: Department of Thoracic Surgery, Jinan Central Hospital, Jinan, China, from December 2021 to May 2022. Methodology: To...

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Maternal Serum Cripto-1 Levels in Pregnancies Complicated with Placenta Previa and Placenta Accreta Spectrum (PAS)

By Zeynep Gedik Ozkose, Suleyman Cemil Oglak, Mustafa Behram, Ozge Ozdemir, Zuat Acar, Ismail Ozdemir

ABSTRACT Objective: To examine maternal serum Cripto-1 levels in placenta accreta spectrum (PAS) pregnancies and compare them with placenta previa (PP) cases and healthy pregnancies. Study Design: A prospective case-control study. Place and Duration of Study: Kanuni Sultan Suleyman Training and Res...


Clinical Significance of Methyltransferase-like 16 Expression in Epithelial Ovarian Cancer

By Changshu Li, Chun Qiao, Huafeng Ding, Yonghong Luo

ABSTRACT Objective: To detect methyltransferase-like (METTL) 16 expression in epithelial ovarian cancer (EOC) by immunohistochemistry (IHC), and its relationship with clinicohistopathological parameters and prognosis. Study Design: Observational study. Place and Duration of Study: Department of Gyna...

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Outcomes Associated with Indwelling Momentary Probe for Congenital Nasolacrimal Duct Obstruction Treatment

By Xuemei Han, Yang Bian, Bo Yu

ABSTRACT Objective: To compare the outcomes of congenital nasolacrimal duct obstruction (CNLDO) patients undergoing nasolacrimal duct obstruction (NLD) probing in whom momentary probe indwelling was and was not performed. Study Design: Randomised controlled trial. Place and Duration of Study: D...

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Peroxinitrite and Malondialdehyde as Biomarkers for Overactive Bladder

By Suleyman Sagir, Omer Bayrak, Omer Turgut, Sule Allahverdi, Hasan Ulusal

ABSTRACT Objective: To measure urine malondialdehyde (MDA) and urine peroxynitrite (ONOO) levels in patients with overactive bladder (OAB), and compare them with healthy individuals; to determine the change of those markers in OAB patients prescribed antimuscarinic drugs. Study Design: An observatio...


Sternal Fractures due to Blunt Chest Trauma

By Shi-Min Yuan

ABSTRACT The present article aimed to give an overview of sternal fractures and discuss their management and prognoses. The retrieved pertinent publications of 2011–2021 constituted the materials of the present study. The misdiagnosis rate of X-ray was 5.5% and that of sonography was 6.3% for ...


Efficacy of Ganciclovir in Cytomegalovirus Retinitis via Intravitreal Route in AIDS Patients

By Uzma Naz, Saliha Naz, Hadees Murad Fahad, Syed Fawad Rizvi

ABSTRACT A series of nine eyes of five patients at LRBT Tertiary Teaching Eye Hospital, from July 2020 to June 2021 is reported. Five patients with high clinical suspicion of CMV Retinitis were treated with weekly intravitreal injections of 2.0 mg ganciclovir for 3 weeks. Pre- and post-injection vis...


Patellofemoral Anatomical Measurements on MRI in Patient with Suprapatellar Fat Pad Edema and Mass Effect

By Suna Sahin Ediz, Senem Senturk, Adnan Kabaalioglu

ABSTRACT Objective: To evaluate the impact of patellofemoral joint anatomical measurements of patients with anterior knee pain who were diagnosed with suprapatellar fat pad (SPFP) impingement syndrome (SP-FPIS) by magnetic resonance imaging (MRI). Study Design: A prospective, descriptive study....


Evaluation of Viral and Bacterial Pathogens in the Central Nervous System Infections with Multiplex PCR

By Sedef Zeliha Oner, Ilknur Kaleli, Melek Demir, Ergun Mete, Ahmet Caliskan

ABSTRACT Objective: To evaluate the bacterial and viral causes of central nervous system (CNS) infection by multiplex PCR. Study Design: Descriptive study. Place and Duration of Study: Department of Medical Microbiology, Pamukkale University Faculty of Medicine, Turkey, from March 2016 to December 2...

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Thoracoscopic Partial Pneumonectomy with and without Postoperative Thoracic Drainage Tube

By Jie Dang, Xu Zhao

ABSTRACT Objective: To compare thoracic drainage tube placement on clinical outcomes and serum CRP, IL-6, cortisol in patients undergoing thoracoscopic partial pneumonectomy. Study Design: Analytical study. Place and Duration of Study: Yulin Second Hospital, China, between January 2017 and January 2...


Cholera Outbreak 2022 in Karachi: A Report on Serotype and Antibiotic Susceptibility Pattern

By Qurat ul Ain Zahid, Nazia Khursheed, Fareeha Adnan, Adeel Zafar

ABSTRACT Objective: To identify the bacterial agent responsible for the surge of cases of acute diarrhoeal disease in Karachi, Pakistan, and assess the antimicrobial susceptibility pattern of the isolates. Study Design: Observational study. Place and Duration of Study: Department of Microbiology, In...


Takayasu Arteritis with Isolated Headache and Neck Pain

By Nazia Arain, Shamsuddin Shaikh, Jawad Ali

ABSTRACT Takayasu Arteritis (TA), a chronic inflammatory condition of the aorta and its major branches, causes narrowing and ultimate occlusion of major vessels and may manifest as cerebrovascular insufficiency, organ ischemia, and systemic arterial hypertension (HTN). Herein, we report a case of a ...


Digital Necrosis Due to Septic Embolism: An Unseen Complication of Gangrenous Cholecystitis

By Nazmi Ozer, Abdullah Sahin

ABSTRACT Gangrenous cholecystitis is one of the most severe complications of cholelithiasis. It causes serious morbidity and mortality. The main pathology in this complication is progressive vascular insufficiency, which may lead to necrosis and perforation of the gallbladder wall. Vascular insuffic...


A Rare Complication of The Heart Rate Strap Use in A Marathon Runner: Mondor’s Disease of the Breast

By Tuba Selcuk Can, Turkan uz Ikizceli

ABSTRACT This is the first case report of Mondor’s disease diagnosed in a marathon runner developed due to tight heart rate strap. A 41-year female marathon runner was admitted to the hospital with a cord-like soft tissue swelling under her breast, which was confirmed by physical examination. ...


Stem Cell Transplantation in Glanzmann's Thrombasthenia: A Report of Two Adult Patients

By Jehanzeb Ur Rehman, Fayyaz Hussain, Syed kamran Mahmood, Qamar Un Nisa, Nighat Shahbaz, Mehreen Ali Khan

ABSTRACT Glanzmann’s thrombasthenia (GT) is an autosomal recessive bleeding disorder characterised by mucocutaneous bleeding. At molecular level, defect in platelet receptor glycoprotein (GP) IIb/IIIa leads to defective platelet aggregation. Anti-fibrinolytic agents, platelet transfusions, and...


A Delayed Presentation of Arginase Deficiency Presenting with Status Epilepticus

By Asburce Olgac, Eren Yildiz, Arzu Yilmaz, Cigdem Seher Kasapkara, Serdar Ceylaner, Bulent Alioglu

ABSTRACT Arginase 1(ARG1) deficiency is a rare disorder of the urea cycle. The presentation is usually late, leading to loss of intellectual milestones, spasticity and liver involvement. Hyperammonemic crises are rarely encountered. We herein present a case of a 16-year immigrant girl of Syrian orig...


Surgery for an Isolated Adrenal Metastasis of Gastric Cancer

By Ali Alemdar, Seracettin Egin, Ismayil Yilmaz, Selma Sengiz Erhan, Recep Yilmaz Bayraktarli

ABSTRACT Adrenal metastasis is considered a rare hematogenous metastasis that develops after gastric cancer surgery. The chances of curative surgery are very low. It is usually unresectable. We aim to present a case of isolated adrenal metastasis that developed in a patient, who underwent a total ga...


Liver Transplantation in HIV-Infected Patient

By Abdul Wahab Dogar, Kaleem Ullah, Shams Uddin, Hafiz Bilal Ahmed

ABSTRACT HIV infections have always been a stigma, and the majority of transplant centres avoid liver transplantation in patients having end-stage liver disease patients with HIV coinfection. HIV patients with end-stage liver disease having undetectable HIV viral load, CD4+ cell count of >100/ml,...


Peripheral Lymphocyte Count and Viral Clearance in COVID-19

By Wen Luo, Wanyu Wang, Dinghui Wu, Lijuan Jian, Yihua Lin, Xiangyang Yao

ABSTRACT The objective of the study was to investigate whether the peripheral lymphocyte count was independently negative association with viral clearance time of SARS-CoV-2 in Chinese patients with COVID-19. Total 202 patients were chosen for the last data analysis. The patients' mean...


Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis

By Maliha Khalid Khan, Imran Ahmad Khan, Ammara Liaquat

ABSTRACT This study aimed to assess the synergistic effects of curcumin with and without strengthening exercises in rheumatoid arthritis (RA). Randomised controlled trial study was conducted from May 2021 to December 2021. Ninety patients were randomised into two groups. Group A was treated with str...


Use of Bilateral Superficial Cervical Plexus Block for Excision of Thyroglossal Duct Cyst in an ASA III Patient

By Abdulhakim Sengel, Evren Buyukfirat, Ramazan Aslanparcas


An Intriguing Case of Back Pain in an Elderly Male

By Muhammad Mohsin Sajjad, Adnan Nasir, Hamid Shahzad


Need for Development and Validation of Sarcopenia Screening Tools in Pakistan

By Nawazish Zehra, Lena Jafri, Aysha Habib Khan


Gender Preference of Colorectal Patients

By Asma Abdul Razzak Bandhani


UGT1A1 Genetic Testing for Irinotecan Should be done before Starting the Treatment, Rather than after the Development of Serious Adverse Drug Reactions

By Lingti Kong, Li Rong, Muhua Wang


SUPPLEMENT

Supplement | August 2022 | Volume 32
Impact of Intragastric Balloon: A Rare Complication

By Ghulam Mujtaba, Rida Zehra, Fizra Balkhi, Numra Shaikh

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Invasive and Non-invasive Ductal Carcinoma within Malignant Phyllodes Tumour with Axillary Lymph Node Metastases

By Osman Erdogan, Alper Parlakgumus, Zeynel Abidin Tas, Kemal Yener, Umit Turan

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Cutaneous T-cell Lymphoma Predisposing to Recurrent Infective Endocarditis by Methicillin-resistant Staphylococcus Aureus (MRSA) in a Patient with Intracardiac Defibrillator (ICD)

By Muhammad Azam Shah, Muhammad Adil Soofi, Faisal Alsmadi, Muhammad Amin Ur Rehman, Faisal Abdullah Alghamdi

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Broad Complex Tachycardia, Addison's disease, and Ascending Flacid Paralysis: An Interesting Case on Cardiology Floor

By Nauman Ali

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Two Cases of Interrupted Inferior Vena Cava with Azygos / Hemiazygos Continuation

By Saerah Iffat Zafar, Aliya Halim, Waqas Khalid, Mobeen Shafique, Hina Nasir

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Persistent Left Superior Vena Cava: A Rare Finding for the Internists

By Syed Mohammad Haleem

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Duodenal Ulcer Perforatıon after Actıvated Charcoal Treatment

By Nazmi Ozer, Abdullah Sahin

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A Novel Variant in Paired Box 3 Gene-related with Waardenburg Syndrome Type-1 in an Afghan Family

By Mustafa Dogan, Recep Eroz

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The Case with Short Stature and Intellectual Disability Caused by a Novel 2q12 Duplication

By Pinar Kocaay, Ahmet Cevdet Ceylan, Derya Tepe

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Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report

By Erkan Somuncu, Ismail Hakki Alp Solak

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Giant Sigmoidal Lipoma Protruding Through Anal Canal and Causing Sigmoido-rectal Intussusception

By Ali Surmelioglu, Serhat Ozer

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Recurrent Bleeding From a Duodenal Ulcer Halted by Laparoscopic Oversewing Under Endoscopic Guidance

By Feng Chi, Shenkang Zhou

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Granulomatous Inflammation of Greater Omentum Caused by a Migrating Fishbone

By Tao Fan, Chao-Qi Wang, Ying-Jie Song, Wan-Yan Wu, Ya-Nan Wei, Xue-Tao Li

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Neuroendocrine Tumour of the Gallbladder Diagnosed after Cholecystectomy

By Halil Ibrahim Tasci, Esra Zeynep Coskunoglu, Emin Turk, Erdal Karagulle

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A Rare Case of Female Bladder Outlet Obstruction: Severe Introital Stenosis

By Muhammed Fatih Simsekoglu, Oktay Ozman, Mehmet Hamza Gultekin, Bulent Cetinel

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Lafora Body Epilepsy: A Challenging Diagnosis

By Ali Zohair Nomani, Haris Majid Rajput, Hanna Nomani

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Sturge-weber Syndrome with Bilateral Fronto-parieto-temporal Lobe Atrophy and Bilateral Leptomeningeal Angiomatosis: A Rare Case

By Ashok Kumar, Imtiaz Ali Panhwar, Bushra Rehan, Kanchan Shadani

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It does Exist! Traumatic Hemorrhage in Septum Pellucidum

By Murat Seyit, Arif Osun, Atakan Yilmaz, Mert Ozen, Duygu Aras Seyit

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Atypical Presentation of a Primary Thymic Adenocarcinoma

By Hasan Ersoz, Ebru Cakir, Utku Oflazoglu, Berna Dernek

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Colonic Metastasis from Primary Tonsillar Squamous Cell Carcinoma: A Rare Cause of Large Bowel Obstruction

By Tayfun Kaya, Semra Demirli Atici, Dudu Solakolu Kahraman, Huseyin Salih Semiz, Duygu Kahraman

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Glucagonoma Syndrome: A Rare Paraneoplastic Disorder due to Neuroendocrine Tumor of the Pancreas

By Muhammed Aasim Yusuf, Shafqat Mehmood, Jhanzeb Iftikhar, Muhammad Saqib, Muhammad Zeeshan Siddique, Wania Imtiaz

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Control of Oesophageal Tumour-related Bleeding with a Fully Covered Self-expandable Metallic Stent (SEMS) Insertion

By Muhammad Zeeshan Siddique, Muhammad Saqib, Jhanzeb Iftikhar, Muhammed Aasim Yusuf

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Co-existence of Papillary and Medullary Thyroid Carcinoma: Reports of Three Cases

By Murat Calapkulu, Ozen Oz Gul, Soner Cander, Muhammed Fatih Sagiroglu, Ozlem Saraydaroglu, Erdinc Erturk, Canan Ersoy

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Primary Hepatic Sarcomatoid Carcinoma Presenting with Dysphagia: A Rare Presentation

By Khadim Hussain Samejo, Rajesh Mandhwani, Zain Majid, Muhammed Mubarak, Nasir Hassan Luck

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Osteoid Osteoma of Retromolar Trigone: Report of a Rare Case

By Faheem Ahmed, Hamza Hassan Mirza, Zahoor Ahmed Rana, Noaman Ghauri

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Solitary Plasmacytoma in a Patient Presenting with Taste Disturbance

By Ugur Ergun, Ayse Uysal, Hasmet Yazici

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Inflammatory Pseudotumour of Temporal Bone in a Multiple-Comorbidity Patient

By Yao Wang, Chih-Hung Wang, Hsin-Chien Chen

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Carpometacarpal Joint Dislocations as a Rare Cause of Hand Pain

By Ali Celik

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T-cell Acute Lymphoblastic Leukemia in an Infant: A Case Report and Review of Literature

By Neelum Mansoor, Naeem Jabbar

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Laparoscopic Management of Intestinal Obstruction due to a Tight Muscular Cuff Following Transanal Endorectal Pull-through for Hirschsprung’s Disease

By Vanesa Villamil, Juana Maria Sanchez Morote, Maria Josefa Aranda Garcia, Ramon Ruiz Pruneda, Maria Fernandez Ibieta

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A Rare Case of Propionic Acidemia in a Six Months Female Child

By Sobia Irum, Ambreen Rehman, Muhammad Aamir, Zujaja Hina Haroon, Nayyar Chaudhry, Afshan Bibi

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First Documented Case of Pulmonary Alveolar Proteinosis with Atopy Presenting Secondary to CSFR2B Mutation

By Ayse Senay Sasihuseyinoglu, Dilek Ozcan, Arbil Avci, Gursu Kiyan

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Association between Serum Carcino-embryonic Antigen Levels and Micropapillary Bladder Cancer Metastasis in an Elderly Male

By Caner Ediz, Neslihan Kaya Terzi, Serkan Akan, Omer Yilmaz

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Male Urethral Diverticulum with Stones Presenting as Acute Urinary Retention

By Syed Muhammad Nazim, Roshane Shahid Rana, Kaleem Khan Mirani

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Solid Renal Mass in a Transplanted Allograft Kidney: Mucinous Tubular and Spindle Cell Renal Cell Carcinoma

By Erdinc Dincer, Osman Murat Ipek, Sukran Sarikaya Kayipmaz, Oktay Akca

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The Use of Lumbar Drain for Spinal Cord Protection in a Thoraco Abdominal Aortic Aneurysm Surgery

By Saima Rashid, Mohammad Hamid, Sameer Ahmed Malick

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