Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Important Announcement for Authors

"As a large number of case reports are awaiting publication, JCPSP has decided to stop acknowledging Case Reports for a certain period of time until the backlog is cleared. Therefore, case reports are regretted from processing".

Latest Articles
Volume 31 | Issue 7 | July 2021
Asian Obesity Paradox: Implications for Healthcare Management Approaches

By Sikandar Hayat Khan

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The Value of Carotid Intima-Media Thickness in the Detection of Atherosclerosis in HIV (+) Patients Subclinical Atherosclerosis in HIV (+)

By Selin Ozdemir, Emre Ozdemir, Bilge Birlik, Tuna Demirdal

ABSTRACT Background: To evaluate the role of the traditional risk scoring system (TRSS) in detecting subclinical atherosclerosis in HIV (+) patients. Study Design: Cohort study. Place and Duration of Study: Infectious Diseases Clinic, Izmir Katip Çelebi University, Atatürk Training ...

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A Comparative Analysis of Superoxide Dismutase 1 Level in Diabetics with and without Neuropathy

By Kanwal Huma, Khadija Mehboob, Amir Rashid, Asifa Majeed

ABSTRACT Objective: To compare superoxide dismutase 1 (SOD1) levels in diabetes mellitus patients with and without neuropathy. Study Design: Cross-sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-1 of the Department of Biochemistry and Molecular Biology, Army Medical ...

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Percutaneous Cholecystostomy in High-risk Geriatric Patients with Acute Cholecystitis

By Hasan Gündoğdu, Gokhan Demiral

ABSTRACT Objective: To determine the results of high-risk geriatric patients treated with percutaneous cholecystostomy (PC) for acute cholecystitis (AC). Study Design: Observational study. Place and Duration of Study: Department of Interventional Radiology, Recep Tayyip Erdogan University Hospital, ...

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Association of Alpha 1-antitrypsin Deficiency and Genetic Predisposition in Primary Spontaneous Pneumothorax

By Taner Sahin, Ibrahim Ethem Ozsoy, Mehmet Akif Tezcan, Derya Kocer, Murat Erdogan

ABSTRACT Objective: To determine the association of alpha-1 antitrypsin deficiency (AATD) in patients diagnosed with primary spontaneous pneumothorax (PSP), the presence of the SERPINA 1 gene, and the phenotype in patients with low enzyme values. Study Design: Cross-sectional descriptive study. Plac...

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BTD Gene Mutations in Biotinidase Deficiency: Genotype-Phenotype Correlation

By Ozlem Oz, Meryem Karaca, Nurgul Atas, Ataman Gonel, Mujgan Ercan

ABSTRACT Objective: To identify the biotinidase (BTD) gene mutations in patients with biotinidase deficiency in our region; and to determine the phenotype-genotype correlations in the presence of clinical findings. Study Design: Descriptive study. Place and Duration of Study: Department of Medical G...

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Distribution of High-risk Human Papillomavirus Genotypes in Cervical Secretions in Punjab

By Sadia Minhas, Muhammad Kashif, Zobaria Rehman, Muhammad Bilal Pasha, Muhammad Idrees, Farheen Ansari

ABSTRACT Objective: To determine the high risk-human papillomavirus (HR-HPV) prevalence, genotype distribution, and associated risk factors in women with general gynaecological problems. Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Lady Wallingdon Hospital, Lahore f...

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The Role of FDG PET/CT to Evaluation of Axillary Lymph Nodes after Neoadjuvant Chemotherapy in Breast Cancer

By Eda Tanrikulu Simsek, Ezgi Coban, Elif Atag, Serkan Gungor, Murat Sari, Gunay Gurleyik

ABSTRACT Objective: To determine the diagnostic value of breast and axillary maximum standard uptake (SUVmax) values for predicting ypT0 and ypN0 separately. Study Design: A descriptive study. Place and Duration of Study: Department of Medical Oncology, Haydarpasa Numune Training and Research Hospi...

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Surgical Resection Length and Harvested Lymph Nodes in Colon Cancer

By Mustafa Taner Bostanci, Ibrahim Yilmaz

ABSTRACT Objective: To determine the relationship between resected specimen length and tumor location, the number of LN harvested (LNh), and the positive LN ratio (LNR) in colon cancer. Study Design: A descriptive study. Place & Duration of Study: Department of General Surgery, University o...

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Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma

By Huseyin Alakus, Mustafa Kaya, Murat Can Mollaoglu, Mustafa Göksu, Hatice Ozer, Kursat Karadayi

ABSTRACT Objective: To investigate the association between the ratio of negative/positive lymph nodes (RNP) and other clinic pathological parameters. Study Design: Descriptive study. Place and Duration of Study: Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to D...

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Investigation of Hereditary Cancer Predisposition Genes of Patients with Colorectal Cancer: Single-centre Experience

By Neslihan Duzkale, Ozlem Oz, Tugba Taskin Turkmenoglu, Kadir Cetinkaya, Tulay Eren, Suayip Yalcin

ABSTRACT Objective: To investigate the genetic causes of colorectal cancers (CRCs); and to determine the genotype-phenotype correlation. Study Design: Descriptive study. Place and Duration of Study: Department of Medical Genetics, Diskapi Yildirim Beyazit Training and Research, Hospital, Ankara, Tur...

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Role of Intravenous Magnesium Sulphate in Term Neonates with Hypoxic Ischemic Encephalopathy (HIE) in a Low-income Country: A Randomised Clinical Trial

By Muhammad Asif Siddiqui, Tayyaba Khawar Butt

ABSTRACT Objective: To determine the effects of magnesium sulphate in term neonates with hypoxic ischemic encephalopathy (HIE) in reducing mortality and morbidity. Study Design: Randomised clinical trial. Place and Duration of Study: Department of Neonatology, Services Hospital, Lahore, Pakistan fro...

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Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratio as Predictive Biomarkers for Early-onset Neonatal Sepsis

By Shujian Zhang, Xue Luan, Wei Zhang, Zhengyong Jin

ABSTRACT Objective: To determine the predictive significance of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in early-onset neonatal sepsis (EONS). Study Design: A descriptive study. Place and Duration of Study: The Neonatal Intensive Care Unit (NICU), Affiliated Hospi...

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A Novel Transabdominal Preperitoneal Hernioplasty Technique in the Repair of Large Inguinal Hernias: The use of Polypropylene Mesh in the form of Plug-patch

By Hasan Calis, Serkan Sengul, Yilmaz Guler, Zulfikar Karabulut

ABSTRACT Objective: To describe the outcome of modified transabdominal laparoscopic preperitoneal (TAPP) hernioplasty repair with plug-patch of polypropylene mesh. Study Design: A descriptive study. Place and Duration of Study: Alanya Alaaddin Keykubat University Training and Research Hospital,...

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Pathological and DNA-based Detection of Tracheobronchial Tuberculosis in China

By Xin Li, Yi Xie, Yongmei Wang, Junping Wu, Xin Sun, Qi Wu

ABSTRACT Objectives: To compare the DNA-based sputum evaluation with histopathology for the diagnosis of tracheo-bronchial tuberculosis (TBTB). Study Design: Case series.   Place and Duration of Study: Tianjin Haihe Hospital, Tianjin Institute of Respiratory Diseases, Tianjin, China, fro...

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Management of Malignant Chest Wall Tumors

By Farhan Ahmad Majeed, Ahmad Ali, Sohail Saqib Chatha, Ghazanfar Ahmad, Adeel Wyne, Nadeem Paracha

ABSTRACT Objective: To analyse the malignant chest wall tumors in terms of histological types and confer option for resection, stabilisation and reconstruction, along with postoperative morbidity and mortality. Study Design: Observational study. Place and Duration of Study: Department of Thoracic Su...

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Targeted Next-generation Sequencing for Reliable Detection of Genetic Status in Breast Cancer

By Hassan Tariq, Asma Gul, Muhammad Zubair, Syed Raza Jaffer, Nadeem Zafar, Ghazala Sadaf

ABSTRACT Objective: To test the germline oncogenic mutations in BRCA1 and BRCA2 genes, associated with triple-negative breast cancer (TNBC) patients under study, by targeted sequencing of their DNA with next-generation sequencing (NGS) platform. Study Design: Cross-sectional observational study. Pl...

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Ischemia-modified Albumin to Evaluate Short-term Prognostic of Patients with Acute Coronary Syndrome

By Huaming Mou, Jiang Shao, Jianming Zhang, Jianjun Yang, Shimei Yu, Hailong Wang

ABSTRACT In patients with acute coronary syndrome (ACS), the predicted short-term result of ischemic modified albumin (IMA) is still not recognised now. The above have been searched in PubMed, Embase, Medline, Cochrane Library databases, and Wanfang databases from the beginning to June 2020. The st...

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Acute Urinary Retention: Should We Call it a Manifestation of Appendicitis?

By Sadaf Sheikh, Umair Javed, Muhammad Akbar Baig

ABSTRACT Acute urinary retention (AUR) is a fairly common presentation in the elderly; but interesting to be noted in a healthy young individual as a manifestation of acute appendicitis. We present a case of a 32-year gentleman with decreased urine output with mild tenderness at the supra-pubic regi...

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A Rare Complication of Chylous Ascites Following Aortobifemoral Bypass Surgery

By Görkem Yiğit, Alp Yildirim, Mustafa Ozdemir, Anil Ozen, Hakki Zafer Iscan

ABSTRACT Injury of the lymphatic trunk during abdominal aortic surgery causes leakage of chyle into the peritoneum, resulting in chylous ascites. A 53-year male, who underwent aortobifemoral bypass surgery for Leriche syndrome in our clinic, presented to the Emergency Department two months postopera...

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Brain Abscess Caused by Lactococcus Lactis in a Young Male

By Intisar Ahmed, Kashif Aziz, Hameed Tareen, Muhammad Arslan Ahmed

ABSTRACT Lactococcus lactis cremoris is one of the gram positive cocci, not known to be pathogenic in humans. We report a case of brain abscess due to lactococcus lactis in an adolescent. An 18-year male with congenitally corrected transposition of great arteries and dextrocardia was admitted with f...

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Challenges in the Management of Multiple Splenic Abscesses caused by Extensively Drug-resistant (XDR) Salmonella Typhi

By Ch. Muhammad Zubair, Muhammad Musa Haider, Muhammad Ameer Musa, Zulfiqar Ali Khosa

ABSTRACT Extensively drug-resistant (XDR) typhoid emerged in Hyderabad, Pakistan in 2016. It spread regionally and globally due to fast travelling. An immuno-competent young male referred by general practitioner, was diagnosed and managed as XDR salmonella typhi with multiple splenic abscesses. We f...

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Nerve-preserving Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Advanced Primary Caecal Cancer Invading Pelvic Side-wall: Report of a Case With Right Leg Limping

By Ethem Unal, Abdullah Yildiz, Sema Yuksekdag

ABSTRACT Radical surgery to achieve optimal cytoreduction in locally advanced caecal cancer may dictate femoral or sciatic nerve resection, especially in cases with pelvic side-wall involvement. In such a situation, gait disturbance is inevitable. A 61-year male with a new-onset right leg limping du...

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Sarcoidosis Presenting with Bilateral Optic Disc Edema as the Initial Presentation

By Merve Beyza Yildiz, Sevcan Balci, Sehnaz Ozcaliskan, Ece Turan Vural

ABSTRACT Sarcoidosis is a chronic, progressive, granulomatous inflammatory disease of unknown etiology that affects multiple organ systems. Granulomatous anterior uveitis is the most common eye finding, and optic nerve involvement at presentation is rarely seen. Here, we report a 43-year man referre...

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Serum Protein Electrophoresis and Immunofixation Electrophoresis Detection in Multiple Myeloma

By Shanshan Zhu, Wei Li, Meilin Lin, Tiemin Li

ABSTRACT The objective of this study was to investigate the diagnostic significance of serum protein electrophoresis and immunofixation electrophoresis detection in diagnosis of multiple myeloma (MM). One hundred and five patients were investigated. The detection rate of M protein by immunofixation ...

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Improved Clinical Competence and Patients Satisfaction: Comparison of Patient-centered, Interdisciplinary Collaborative Round versus Traditional Post-partum Round

By Arshia Javed, Arjumand Sohaila, Irfan Sheikh, Nida Qadir

ABSTRACT The origin of the patient-centered interdisciplinary collaborative round, which involves health care members of all levels at a time, is an effective and emerging approach to offer inpatient healthcare. Traditionally, post-partum rounds at teaching hospitals consisted of separate visits fro...

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Granulocyte to Lymphocyte Ratio among Different Categories of Neonatal Sepsis according to their Vitamin D Status

By Mirza Sultan Ahmad, Hadia Farooq, Rida Fatima, Sumaira Noor Maham

ABSTRACT The objective of this study was to ascertain whether, among the cases of neonatal sepsis, there is any significant difference between GLR (Granulocyte to Lymphocyte ratio) of different groups of patients according to their vitamin D status. One hundred and nine neonates with odd admission ...

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Technical Difficult Subarachnoid Block in a Morbidly Obese Patient: Ultrasound Guidance and Improvisation is the Key to Success

By Anju Gupta, Amita Gupta, Aastha Gaba

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A Rare Case of Primary Paratesticular Adult Ganglioneuroma

By Yavuz Burak Kara, Ekrem Akdeniz

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Mean Platelet Volume may not be Responsible for Aetiology in Patients with Idiopathic Sudden Sensorineural Hearing Loss

By Cengiz Beyan, Esin Beyan

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Incidental Finding of Idiopathic Sub-glottic Stenosis in a Patient Managed for Drug Overdose

By Saad Ishtiaq, Shankar Lal, Ehtesham Khan, Muhammad Anwar Malik

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Upper GI Obstruction Presenting as Failure to Thrive: A Case of Achalasia

By Saima Gillani, Aziz Ullah, Syed Faiz Muhammad Shah

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Special Issue

Special Supplement 2 | Volume 31 | Year 2021
High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients

By Eren Yildiz, Emrah Cigri, Zubeyde Dincer, Mehmet Ali Narsat, Busra Calisir

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Prealbumin: A New Biomarker for Predicting Prognosis in Patients with Severe COVID-19

By Kubilay Issever, Ahmed Cihad Genc, Deniz Cekic, Ilhan Yildirim, Ahmed Bilal Genc, Selcuk Yaylaci

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Characteristics of Patients Presenting with COVID-19 from Balochistan Province and Lessons Learnt

By Abida Munir Badini, Aurangzeb Badini, Naeem M. Mengal, Kashmira Nanji

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The Strategic Role of Healthcare Professionals in the Battle Against COVID-19: Do We Really Need Help from Community Pharmacists?

By Kashif Ali, Mehwish Wajdi, Osama Al Quteimat

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Obstetrics and COVID-19 Experience: Challenges and Strategies Adapted by a Tertiary Care Hospital in a Developing Country

By Shazia Fakhar, Irram Asghar, Muhammad Ashraf, Ejaz Khan, Sumeyya Azam

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Lung Biopsy in Coronavirus-19 Pneumonia: A Case Report and Review of Literature

By Nadia Mamoon, Imran Nazir Ahmad, Atif Iqbal Rana, Haseeb Haider Zia

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Can COVID-19 Cause Pancreatitis? A Rare Complication of SARS-CoV-2 Infection

By Muhammad Hanif, Abdul Wali Khan, Sadiq Ullah, FNU Sundas, Sheraz jamal Khan

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COVID-19-induced Guillain-Barre Syndrome: A Rare Complication of SARS-CoV-2 Infection

By Muhammad Hanif, Abdul Wali Khan, Muhammad Aslam Khan, FNU Sundas, Sheraz Jamal Khan

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Acute Hepatitis as a Rare Presentation of COVID-19

By Abat Khan, Ihtisham Qayum, Abdul Wali Khan, Muhammad Hanif, Awais Naeem

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Sacral Stress Fracture due to Excess Weight Gain during Pregnancy while Self-Quarantining during the COVID-19 Pandemic

By Rıfat Sahin

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COVID-19-related Abdominal Aortic Thrombosis

By Cengiz Güven

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Acute Ischemic Stroke Associated with COVID-19

By Buse Cagla Ari

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Kawasaki Shock Syndrome and Covid-19

By Sana Ashraf, Farah Shams Abbasi, Mehnaz Atiq

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Post-COVID Neuromyelitis Optica Spectrum Disorder

By Shumaila Rafique, Areeba Wasim, Tipu Sultan, Arsalan Ahmad

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COVID-19 in Hemodialysis Patients

By Sonia Yaqub, Amna Hamid, Zarghoona Naeem

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COVID-19 in Individuals with Drug Abuse - A Case and Thoughts from Emergency Physician

By Sadaf Sheikh

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The use of Pregabalin in Intensive Care Unit in the Treatment of Covid-19-related Pain and Cough

By Sinan Pektas, Canan Gursoy, Semra Gumus Demirbilek

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Peer-assisted Learning (PAL) as an Instructional Tool in Dental Interns in Corona Virus Disease (COVID-19) Scenario

By Thorakkal Shamim

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Delirium in COVID-19: “New Normal” for Care of Older Adults

By Sadaf Sheikh

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Nasopharyngeal Swab Collection Methods for COVID-19: Suggestions from COVID-19 Diagnosticians

By Sadaf Sheikh

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How COVID (Pandemics) Impacted Training of Medical Students, Trainees, and Residents?

By Seema Rawat, Pankaj Kumar Sharma, Amit Narang

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Thrombotic Thrombocytopenia and Central Venous Sinus Thrombosis Post - COVID-19 Vaccination and its Treatment with Heparin Alternatives

By Sadaf Sheikh

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Risk of Invasive Fungal Infections and Osteonecrosis of Jaw in Patients Exposed to Current Therapeutic Drugs for COVID-19

By Muhammad Adil Asim

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