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Volume 33, 12 Issues, 2023

Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.

The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.

Important Announcement for Authors

"A companion journal of JCPSP (the official journal of CPSP) has been launched by the name of JCPSP Case Reports. Submission of Case Reports is now open."
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Latest Articles
Volume 33 | Issue 9 | September 2023
Role of Digital Health Tools in Improving Maternal and Adolescent Mental Health Services in Pakistan: A Way Forward

By Armughan Tauheed Farooqui, Sehrish Karim, Nurose Karim

Identification and Association of Polymorphism rs2073618 of the Osteoprotegerin Gene in Type 2 Diabetics with and without Retinopathy

By Erum Tariq, Palvasha Waheed, Asifa Majeed, Amir Rashid

ABSTRACT Objective: To identify and determine the association of SNP (rs2073618) of OPG gene in diabetics with and without retinopathy and in healthy controls. Study Design: Descriptive study. Place and Duration of the Study: Department of Biochemistry and Molecular Biology, Army Medical College, Ra...

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Role of SLC44A3-AS1 Enhancer RNA in Esophageal Cancer Prognosis

By Kai Kang, Jingyi Wu, Yajun Mao, Jindan Kai, Si Chen, Fei Xiong

ABSTRACT Objective: To identify key enhancer RNAs (eRNA) in esophageal cancer through a comprehensive analysis and explore its importance in esophageal cancer. Study Design: An observational study. Place and Duration of the Study: Department of Thoracic Surgery, Hubei Cancer Hospital affiliated to ...

Effect of Pap Smear Cytology, HPV Genotyping on the Concordance of Colposcopy and Conization Results

By Hanife Saglam, Funda Atalay

ABSTRACT Objective: To evaluate the conization results performed due to human papillomavirus (HPV), smear, colposcopy results or clinician's decision and determine the factors that predict ≥CIN2. Study Design: Retrospective comparative study. Place and Duration of the Study: Department of G...

Prevalence and Association of Transfusion-Transmissible Infections with Age of Blood Donors: A Regional Transfusion Centre Study in Northern Pakistan

By Nargis Sabir, Tahir Ghafoor, Sarah Fatima, Rehan Lodhi, Asad Mehmood, Gohar Zaman

ABSTRACT Objective: To evaluate the prevalence and association of Transfusion-Transmissible Infections (TTIs) with age of blood donors in a regional transfusion centre located in Northern Pakistan. Study Design: Descriptive study. Place and Duration of the Study: Armed Forces Institute of Transfusio...

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Assessment of Acceptability of Pre-exposure Prophylaxis for HIV Prevention Among Men Who Sex with Men and Transgender Community in Pakistan

By Usman Ali, Safdar Kamal Pasha, Rupa Patel, Heather-Marie Schmidt, Arshad Altaf

ABSTRACT Objective: To assess the level of acceptability of oral pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) and transwomen (TW) in Pakistan. Study Design: Cross-sectional study. Place and Duration of the Study: Online study portal from September to November 2021. Methodolo...

Impact of Bolus/Basal Insulin Ratio on HbA1c and Lipid Profile in Adult Patients with Type 1 Diabetes Mellitus

By Murat Calapkulu, Muhammed Erkam Sencar, Ilknur Ozturk Unsal, Davut Sakiz, Mustafa Ozbek, Erman Cakal

ABSTRACT Objective: To evaluate the existence of any relationship between the bolus/basal (B/b) insulin ratio and HbA1c and lipid profile in patients with Type 1 Diabetes mellitus (T1DM) on a basal–bolus treatment regimen. Study Design: Retrospective observational study. Place and Duration of ...

Optimising Preeclampsia First-Trimester Screening Using Three Parameters

By Shehla Baqai, Shazia Tufail, Anam Waheed, Qurat Ul Ain Hanif

ABSTRACT Objective: To evaluate the performance of first-trimester preeclampsia-screening algorithm in predicting preeclampsia (PE). Study Design: Observational study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, Combined Military Hospitals (CMH) Lahore, Pakistan, betwe...

HIPEC in Ovarian Cancer: When and to Whom?

By Ozturk Ates, Bulent Aksel, Mehmet Hadi Akkus, Irem Oner, Cemil Yuksel, Mutlu Dogan

ABSTRACT Objective: To evaluate the optimal candidates for hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) in ovarian cancer. Study Design: Descriptive study. Place and Duration of the Study: Health Sciences University, Dr. Abdurrahman Yurtasian Ankara Oncolog...

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Efficacy and Safety of Combined Chemotherapy Regimens with Bevacizumab in Platinum-sensitive Ovarian Cancers

By Fatih Tay, Mustafa Buyukkor, Ozturk Ates

ABSTRACT Objective: To determine the differences in terms of overall survival in platinum-sensitive ovarian cancer (PSOC) patients undergoing various chemotherapy protocols, and to demonstrate patient tolerance, toxicity, and efficacy data with the use of bevacizumab in different protocols. Study De...

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Adjuvant Capecitabine after Neoadjuvant Chemotherapy in Triple Negative Breast Cancer with Lymph Node Metastasis

By Irem Oner, Alper Turkel, Cengiz Karacin, Erdogan Seyran, Pinar Kubilay Tolunay
, Omur Berna Cakmak Oksuzoglu

ABSTRACT Objective: To evaluate the effect of complete pathological response (pCR) on prognosis in patients with axillary lymph node-positive triple-negative breast cancer (TNBC) and the efficiency of adjuvant capecitabine. Study Design: Analytical study. Place and Duration of the Study: University...

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Comparison of Oxidant and Antioxidant Status in the Aqueous Humour of Cataract Patients with and without Type 2 Diabetes Mellitus

By Shoaib Bin Aleem, Amber Farooq, Teyyeb Azeem Janjua

ABSTRACT Objectives: To compare the total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) in the aqueous humour of cataract patients with and without type 2 diabetes mellitus (T2DM). Study Design: Cross-sectional analytical study. Place and Duration of the St...

Changes in Corneal Biomechanical Properties after Laser-Assisted in situ Keratomileusis and Photorefractive Keratectomy in Myopia

By Sadia Humayun, Yumna Waheed Bangash, Mazhar Ishaq, Habiba Yasmeen

ABSTRACT Objective: To compare changes in corneal biomechanical properties after laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in low and moderate myopia by Ocular Response Analyzer. Study Design: Quasi-experimental study. Place and Duration of the Study: Armed ...

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Radiological and Genetic Evaluation in Hypotonic Infants

By Selen Gur, Gurkan Gurbuz, Hilmi Tozkir

ABSTRACT Objective: To investigate the importance and diagnostic yield of genetic and radiological evaluations in children with hypotonia. Study Design: Comparative observational study. Place and Duration of the Study: Department of Pediatrics Neurology, Namik Kemal University, Tekirdag, Turkey, b...

Predictive Value of Postoperative Indices in Acute Stanford Type A Aortic Dissection

By Chuang Yang, Yuying Wang, Fei Teng, Ying Guo

ABSTRACT Objective: To identify the risk factors for in-hospital mortality in postoperative patients with acute type-A aortic dissection (ATAAD), and combine a simplified-fit index which is feasible and helpful in a clinical practice. Study Design: Observational study. Place and Duration of the Stud...

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Effect of Montelukast Combined with Budesonide on Inflammatory Response and Pulmonary Function in Children with Cough Variant Asthma: A Meta-analysis

By Qingxia Wu, Lianou Wang, Meixia Wu, Hua Lin

ABSTRACT This meta-analysis aimed to compare the efficacy of montelukast (MKST) combined with budesonide (BUD) and BUD alone in the treatment of pulmonary inflammation and pulmonary function in children with cough variant asthma (CVA). Five electronic databases were searched for studies about MKST+B...

Efficacy of Endotracheal Tube Cuff Modification in Preventing Ventilator-associated Pneumonia

By Yanshuo Wu, Congcong Zhao, Meirong Sun, Jingjing Bu, Zhenjie Hu, Yanling Yin

ABSTRACT The aim of this study was to evaluate the effect of modifying the cuff on preventing ventilator-associated pneumonia (VAP). PubMed, Embase and Cochrane Library were systematically searched from inception to April 2022, for randomised controlled trials (RCTs) that compared the effe...

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Comparison of Rapid Antigen Detection Test with Reverse Transcription Polymerase Chain Reaction in Highly Suspected COVID-19 Patients

By Muhammad Abdur Rahman Afridi, Zafar Ali, Naveed Iqbal

ABSTRACT Objective: To compare Rapid Antigen Test (RAT) with Reverse Transcription Polymerase Chain Reaction (RT-PCR) in highly suspected COVID-19 patients and to determine its diagnostic parameters. Study Design: Hospital-based, descriptive/observational study. Place and Duration of the Study: Depa...

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Cervical Mediastinoscopy as a Diagnostic Tool for Mediastinal Lymphadenopathy

By Farhan Ahmad Majeed, Kamran Raheem, Usama Zafar, Sohail Saqib Chatha, Ahmad Raza, Arshman Rauf

ABSTRACT Objective: To determine the yield of cervical mediastinoscopy in determining causes of mediastinal lymph node enlargement. Study Design: Observational study. Place and Duration of the Study: CMH Rawalpindi, Lahore and Multan, from January 2010 to December 2021. Methodology: Patients who und...

Proposing Development of Community-based Physical Activity Park for Elderly Population of Pakistan

By Sana Bashir, Muhammad Iqbal Tariq, Saad Rauf, Arshad Nawaz Malik

ABSTRACT Physical inactivity is known to be as performing less than 150 minutes of moderate- to vigorous-intensity physical activity per week. It poses a substantial risk for not only non-communicable, chronic diseases such as stroke, diabetes etc. but also contributes to the global mortality. Evide...

A Step towards Personalised Cancer Treatment in Lower Middle-income Countries (LMICS): Molecular Tumour Boards

By Agha Muhammad Hammad Khan, Ikram Burney, Zeeshan Ansar, Ahmed Nadeem Abbasi

ABSTRACT Tumour boards are meetings where physicians from various disciplines treating cancer patients meet to recommend evidence-based or the best possible treatment plan. These meetings have evolved with time and now, in every part of the world; site-specific multi-disciplinary tumour boards are e...

Comparison of Delta Spinal Endoscopy and Bilateral Laminotomy for Short-term Patient Outcomes in Degenerative Lumbar Spinal Stenosis

By Dongze Wu, Tianzuo Chen, Rujie Qin

ABSTRACT This prospective randomised controlled trial aimed to compare the clinical efficacy of Delta spinal endoscopy with bilateral laminotomy for degenerative lumbar spinal stenosis (DLSS). Eighty patients with DLSS were randomly assigned to two groups: 40 treatments by Delta spinal endoscopy nam...

Transcranial Sonographic Evaluation of Preterm Neonates Presenting with Seizures and Its Association with Intracranial Abnormalities

By Zobia Saleem, Raham Bacha, Summan Hameed

ABSTRACT This study aimed to determine the association of intracranial abnormalities through transcranial ultrasound in preterm neonates having seizures and to analyse them with preterm classes. It was a cross-sectional analytical study at the Radiology Department of Shalamar Hospital, Lahore. ...

Cancer Staging in Patients with Compromised Renal Function: Is PET/CT an Alternative to Contrast CT Scan?

By Haider Ali, Syed Rashid ul Amin, Abdul Hai

Umbilical Pilonidal Sinus

By Nawaid Farooque Khan, Malik Amna Khatoon, Sarosh Naeem

Dialectal Behavioural Therapy: Is it an Answer to Difficult Questions Posed on Mental Health Professionals by Gen Z?

By Usama Bin Zubair

Flood in Pakistan and Infectious Diseases – The Way Forward

By Adeel Khoja, Naureen Akber Ali, Fizzah Kazim

Problems in Coding Causes of Deaths

By Hilal Aksoy

Ethanol-Associated Prolonged Immobilisation as a Cause of Rhabdomyolysis

By Serdar Ozdemir, Abuzer Ozkan