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Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Important Announcement for Authors

"As a large number of case reports are awaiting publication, JCPSP has decided to stop acknowledging Case Reports for a certain period of time until the backlog is cleared. Therefore, case reports are regretted from processing".

Latest Articles
Volume 32 | Issue 2 | February 2022
What after BCG Fails in Non-muscle Invasive Bladder Cancer?

By Mohammad Hammad Ather

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Effect of Fresh Gas Flow Rate on Thiol/Disulphide Hemostasis and Ischemia-modified Albumin in Laparoscopic Cholecystectomy

By Sermin Eminoglu, Seyda Efsun Ozgunay, Umran Karaca, Asiye Demirel, Mehmet Gamli, Yasemin Ustundag, Derya Karasu, Hasan Eroglu, Ozcan Erel

ABSTRACT Objective: To investigate the effects of low-flow and high-flow anesthesia techniques, administered with sevoflurane during laparoscopic cholecystectomy, on thiol/disulphide homeostasis and serum ischemia-modified albumin (IMA) levels. Study Design: Double-blind, randomised study. Place an...

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Evaluation of the Association between Lumbar Spinal Stenosis and Lumbar Subcutaneous Fat Tissue Thickness by MRI: A Novel Perspective

By Basak Atalay, Fatih Saritepe, Arda Topcam, Hasan Guclu, Mehmet Sabri Gurbuz

ABSTRACT Objective: To evaluate whether lumbar subcutaneous fat tissue thickness (LSFTT) on midsagittal magnetic resonance imaging (MRI) is associated with lumbar spinal stenosis (LSS). Study Design: Observational cross-sectional study. Place and Duration of Study: Department of Radiology and Neuro...

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Accuracy of Metabolic Imaging-guided Transthoracic Biopsy in Lung Cancer

By Mehmet Akif Tezcan, Ibrahim Ethem Ozsoy, Seyhan Karacavus, Hatice Karaman

ABSTRACT Objective: To compare the detection of transthoracic tru-cut biopsy performed on metabolically active areas in positron emission tomography (PET) for the diagnosis of lung cancer, compared to only CT scan-guided biopsy. Study Design: Descriptive study. Place and Duration of Study: Departmen...

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HLA-DQ2 and HLA-DQ8 Alleles in Celiac Disease Patients and Healthy Controls

By Mustajab Alam, Hamid Nawaz Tipu, Dawood Ahmad, Muhammad Hussain, Usama Bin Khalid,         Yumna Ijaz

ABSTRACT Objective: To compare HLA-DQ2 and HLA-DQ8 alleles between celiac disease patients and healthy control group. Study Design: Observational cross-sectional study. Place and Duration of Study: Department of Immunology, Armed Forces Institute of Pathology (AFIP), from April to December 2018. Met...

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Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis

By Halil Ibrahim Tasci, Emin Turk, Ozgur Hilal Erinanc, Serkan Erkan, Ramazan Gundogdu, Erdal Karagulle

ABSTRACT Objective: To investigate factors that may have an effect on recurrence by retrospectively analysing the data of patients who were followed up and treated for idiopathic granulomatous mastitis in this clinic. Study Design: Analytic study. Place and Duration of Study: Department of Gene...

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Effectiveness of Milan Classification in Salivary Gland Aspirations

By Zeynel Abidin Tas, Ozgur Kulahci

ABSTRACT Objective: To determine the effectiveness of Milan system for the evaluation of aspiration cytology to salivary gland lesions classification. Study Design: Cross-sectional observational study.         Place and Duration of Study: Department of Patho...

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Is AST/ALT Ratio a Predictor of In-hospital Mortality in Pulmonary Embolism Patients?

By Muhammed Necati Murat Aksoy, Fahrettin Turna, Irfan Sahin, Suret Agac

ABSTRACT Objective: To document the association between serum transaminases and in-hospital mortality in pulmonary embolism (PE) patients. Study Design: Analytical study. Place and Duration of Study: Patients treated with acute PE in hospital between January 2011 and December 2019 from Sakarya Univ...

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ChromagarTM Col-Apse for Detection of Colistin Resistance in Clinical Isolates of Multidrug Resistant Gram Negative Bacilli

By Saad Ali, Wajid Hussain, Farooq Ahmed, Raja Kamran Afzal, Irfan Mirza, Umer Khurshid

ABSTRACT: Objective: To determine the diagnostic accuracy of CHROMagarTM COL-APSE, for detection of colistin resistance in clinical isolates of multi drug resistant (MDR) gram negative bacilli (GNB). Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Microbiol...

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The Effect of FDG-PET/CT on Clinical Prognostic Staging of Breast Cancer Patients being Planned Neoadjuvant Treatment

By Eda Tanrikulu Simsek, Ezgi Coban, Elif Atag, Serkan Gungor, Fugen Aker, Murat Sari

ABSTRACT Objective: To evaluate the effect of FDG-PET/CT in the radiological imaging of breast cancer (BC) patients planned for neoadjuvant treatment (NAT), on the clinical prognostic stage (CPS). Study Design: A descriptive study. Place and Duration of Study: Haydarpasa Numune Training and Research...

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Deficient Mismatch Repair and Lymphocytic Response to Tumor as Prognostic Markers in Stage II Colon Cancer Patients

By Murat Sari, Elif Atag, Tarik Demir, Eda Tanrikulu Simsek, Ezgi Coban, Makbule Cikrikcioglu

ABSTRACT Objective: To investigate the relationship between colon cancer (CC) subtypes defined by the status of tumor-infiltrating lymphocytes (TIL) and mismatch repair (MMR) combination with clinicopathological features and survival. Study Design: Observational study. Place and Duration of Study:...

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Association of Trace Metals in Patients with Schizophrenia

By Muhammad Hamid Awais, Muhammad Aamir, Afshan Bibi, Sohail Ali, Waqas Ahmed, Sachal Aqeel Safdar

ABSTRACT Objective: To compare the serum concentrations of copper, iron and zinc in schizophrenic patients with healthy individuals. Study Design: Cross-sectional comparison study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (A...

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Does Tamsulosin use before Ureteroscopy Increase the Success of the Operation?

By Murat Demir, Kasim Ertas, Rahmi Aslan, Recep Eryilmaz, Mehmet Sevim, Kerem Taken

ABSTRACT: Objective: To investigate the effect of preoperative tamsulosin use on the success and complications rates of ureteroscopy for ureteral stone removal. Study Design: A randomised clinical trial. Place and Duration of Study: Department of Urology, Dursun Odabas Medical Center, Van Yuzuncu Yi...

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Association between Insulin Resistance and Cognitive Impairment

By Mingyue Chen, Min Zhang, Shenglin Wang, Xiaomi Ding, Yujun Lee, Guohui Jiang

ABSTRACT The objective of the review was to assess the relationship between insulin resistance and cognitive impairment. Medline, Embase, Web of Science and Cochrane Library were searched. Two independent authors selected studies and extracted data. Quality of included studies was assessed by NOS (N...

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Bedside Patent Ductus Arteriosus Ligation in Premature Infants

By Basak Soran Turkcan, Atakan Atalay, Davut Bozkaya, Emre Kulahcioglu, Irfan Tasoglu

ABSTRACT Objective: To determine the safety of on-site bedside patent ductus arteriosus (PDA) ligation, performed by a regional roving surgical team at different neonatal intensive care units (NICUs) in preterm infants with hemodynamically significant PDA (hsPDA). Study Design: A descriptive study....

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Factors Affecting Morbidity, Mortality, and Recurrence in Incarcerated Femoral Hernia

By Tolga Kalayci, Umit Haluk Iliklerden, Mehmet Cetin Kotan

ABSTRACT Objective: To ascertain the factors that govern morbidity, mortality, and recurrence in incarcerated femoral hernia. Study Design: Observational study. Place and Duration of Study: Department of General Surgery, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey, between January ...

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Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer

By Mehmet Bugra Bozan, Fatih Mehmet Yazar, Ilhami Taner Kale, Sezgin Topuz, Ayse Azak Bozan, Omer Faruk Boran

ABSTRACT Objective: To determine the diagnostic value of preoperative immature granulocyte (IG) count and delta neutrophil index (DNI) level before clinical detection of axillary lymph node metastasis. Study Design: Cohort study. Place and Duration of Study: Department of General Surgery, Kahramanma...

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Long-term Visual and Anatomical Outcome after Surgical Management of Epiretinal Membrane

By Lubna Feroz, Syed Fawad Rizvi, Syed Asaad Mahmood, Syeda Aisha Bokhari, Uzma Naz

Objective: To assess the functional and surgical long-term outcomes following epiretinal membrane surgery. Study Design: Case series. Place and Duration of Study: Layton Rahmatulla Benevolent Trust Tertiary Care Eye Hospital, Karachi, from January 2016 to December 2020. Methodology: A medical record...

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Spontaneous Pneumomediastinum in COVID-19 Pneumonia: A Rare Occurence

By Saerah Iffat Zafar, Hina Nasir, Aliya Halim, Atiq Ur Rehman Slehria, Nadeem Zafar

ABSTRACT Spontaneous pneumomediastinum with COVID pneumonia is a rare occurrence with or without accompanying subcutaneous emphysema or pneumothorax. The aim of this study was to establish relation of this complication to severity of lung disease and its clinical outcome. The study was conducted fo...

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Anabolic Steroid-induced Reversible Cardiomyopathy in a Young Non-athletic Female

By Uzma Gul, Muhammad Shahid

ABSTRACT Anabolic androgenic steroid (AAS) abuse is widespread nowadays, not only in athletes but in non-athletic populations; and rapidly becoming a public health challenge. Cardiomyopathy (both dilated and hypertrophic) is a known complication of anabolic steroid use. A 47-year woman presented wit...

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Kleefstra Syndrome with Severe Sensory Neural Deafness and De Novo Novel Mutation

By Huma Arshad Cheema, Nadia Waheed, Anjum Saeed

ABSTRACT Kleefstra syndrome is a rare inherited neuro-developmental condition characterised by facial dysmorphism, microcephaly, hypotonia, developmental delay, and intellectual disability. It is a rare syndrome; and less than 100 cases with different genetic mutations are reported so far. We report...

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Selective Arterial Embolisation of Uterine Arteriovenous Malformation in an Infertile Patient, subsequent Term Pregnancy and Postpartum Recurrence

By Ercument Ciftci, Ozgur Cakir, Ozge Senem Yucel Cicek, Isa Cam

ABSTRACT Uterine arteriovenous malformation (AVM) is a rare entity. This report describes selective catheterisation and embolisation of a uterine AVM in an infertile woman, subsequent spontaneous pregnancy and postpartum recurrence of the AVM treated with a second embolisation procedure. A 22-year w...

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Tricho-Hepato-Eenteric Syndrome: Same Genotype but Different Phenotypes in Two Pakistani Children

By Nadia Waheed, Anjum Saeed, Huma Arshad Cheema

ABSTRACT Tricho-hepato-enteric syndrome (THES) is characterised by infantile diarrhea with characteristic facies, trichorrhexis nodosa and hepatic involvement. The underlying genetic mutation is in tetratricopeptide repeat domain 37 (TTC37) gene. It is a very rare syndrome and only 44 cases hav...

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Neurobrucellosis Presenting with Features of Demyelinating Disorder in a Pediatric Patient

By Muhammad Saeed, Ahmed Al Bishri, Sanaa Gammaa, Abdul Qadir, Saleh Al-Qahtani, Ayed Abdullah Shati

ABSTRACT Brucellosis is an endemic disease in Saudi Arabia, which can present with variable clinical manifestations. It is a zoonotic disease transmitted from animals to humans. Brucellosis is a multisystemic disease that can present with any system involvement; and neurobrucellosis is a serious com...

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Median Arcuate Ligament Compression on Celiac Trunk during Liver Transplantation Procedure

By Kaleem Ullah, Shams Uddin, Abdul Wahab Dogar

ABSTRACT Low insertion of median arcuate ligament (MAL) can cause compression over the celiac trunk with subsequent complications. During liver transplantation procedure, the graft artery is usually anastomosed with the hepatic artery of the recipient, which arises from the celiac trunk. MAL compres...

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Intentional Replantation for a Right Mandibular Premolar

By Sheng-Jin Xue, Qing-Bin Zhang, Wei-Qun Guan

ABSTRACT The present study reports a case of intentional replantation (IR) for a right mandibular second premolar (#45). For the present case, root canal retreatment was first considered after removal of the metal post and core. When the metal post and core could not be removed from #45, micro-apica...

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C-kit Expression in Oral Leukoplakia

By Anand S. Tegginamani, Vanishree H. Shivakumar, Siti Mazlipah B. Ismail, Mannil T. Abraham, Bennete A. Fernandes, Ahmad Termizi B. Zamzuri

ABSTRACT Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia’s malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic &...

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Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis

By Hadi M. Khan, Hamza Hanif

ABSTRACT Peritoneal carcinomatosis (PC) is a common presentation of several gastrointestinal and gynecological malignancies. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is a treatment regimen recently introduced in Pakistan for PC. The goal of cytoreductive surg...

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Short-term Side Effects of Pulse Steroid Treatment in Children

By Gulbaran Koncak, Orkun Tolunay, Asena Unal, Can Celiloglu, Umit Celik

ABSTRACT This study is aimed to evaluate pediatric patients, who were hospitalised in the Department of Pediatrics, University of Health Sciences, Adana City Training and Research Hospital, Turkey, between January, 2019 and January, 2020, and treated with pulse steroid therapy and the early side eff...

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Whole Exome Sequencing: The Tip of the Iceberg

By Neslihan Duzkale

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The Less Expensive Test to Diagnose Helicobacter Pylori Eradication

By Rinaldo Pellicano

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Difference in Patterns of Psychiatric Emergencies in Different Cultures: Do Psychiatric Residents Need More Than Written in Books?

By Usama Bin Zubair

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Mitochondrion-Toxic Compounds Need to be avoided in Leigh Syndrome

By Josef Finsterer

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Routine Procedure Getting Complicated: Iliac Artery Injury during Herniated Disc Surgery

By Zia Ur Rehman

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Back to Ivermectin: Is History Repeating Itself?

By Sadaf Sheikh

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Special Issue

Special Supplement 2 | Volume 31 | Year 2021
High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients

By Eren Yildiz, Emrah Cigri, Zubeyde Dincer, Mehmet Ali Narsat, Busra Calisir

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Vitamin-D Supplementation in COVID-19: Existing Evidence and Gap in Literature

By Muhammad Abbas Abid, Hafsa Majid, Aysha Habib Khan

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Prealbumin: A New Biomarker for Predicting Prognosis in Patients with Severe COVID-19

By Kubilay Issever, Ahmed Cihad Genc, Deniz Cekic, Ilhan Yildirim, Ahmed Bilal Genc, Selcuk Yaylaci

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Can Dentists Prevent Black Fungus in Post-COVID-19 Patients?

By Syed Jaffar Abbas Zaidi, Shahida Maqsood

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Characteristics of Patients Presenting with COVID-19 from Balochistan Province and Lessons Learnt

By Abida Munir Badini, Aurangzeb Badini, Naeem M. Mengal, Kashmira Nanji

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Physical Distancing while Connecting Socially

By Syed Jaffar Abbas Zaidi, Muhammad Taqi

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The Strategic Role of Healthcare Professionals in the Battle Against COVID-19: Do We Really Need Help from Community Pharmacists?

By Kashif Ali, Mehwish Wajdi, Osama Al Quteimat

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Telerehabilitation: Need of the Hour in COVID-19 Pandemic

By Anam Aftab, Shafaq Altaf, Sarah Kafeel

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Obstetrics and COVID-19 Experience: Challenges and Strategies Adapted by a Tertiary Care Hospital in a Developing Country

By Shazia Fakhar, Irram Asghar, Muhammad Ashraf, Ejaz Khan, Sumeyya Azam

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Lung Biopsy in Coronavirus-19 Pneumonia: A Case Report and Review of Literature

By Nadia Mamoon, Imran Nazir Ahmad, Atif Iqbal Rana, Haseeb Haider Zia

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Can COVID-19 Cause Pancreatitis? A Rare Complication of SARS-CoV-2 Infection

By Muhammad Hanif, Abdul Wali Khan, Sadiq Ullah, FNU Sundas, Sheraz jamal Khan

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COVID-19-induced Guillain-Barre Syndrome: A Rare Complication of SARS-CoV-2 Infection

By Muhammad Hanif, Abdul Wali Khan, Muhammad Aslam Khan, FNU Sundas, Sheraz Jamal Khan

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Acute Hepatitis as a Rare Presentation of COVID-19

By Abat Khan, Ihtisham Qayum, Abdul Wali Khan, Muhammad Hanif, Awais Naeem

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Sacral Stress Fracture due to Excess Weight Gain during Pregnancy while Self-Quarantining during the COVID-19 Pandemic

By Rıfat Sahin

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COVID-19-related Abdominal Aortic Thrombosis

By Cengiz Güven

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Acute Ischemic Stroke Associated with COVID-19

By Buse Cagla Ari

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Kawasaki Shock Syndrome and Covid-19

By Sana Ashraf, Farah Shams Abbasi, Mehnaz Atiq

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Post-COVID Neuromyelitis Optica Spectrum Disorder

By Shumaila Rafique, Areeba Wasim, Tipu Sultan, Arsalan Ahmad

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COVID-19 in Hemodialysis Patients

By Sonia Yaqub, Amna Hamid, Zarghoona Naeem

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COVID-19 in Individuals with Drug Abuse - A Case and Thoughts from Emergency Physician

By Sadaf Sheikh

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The use of Pregabalin in Intensive Care Unit in the Treatment of Covid-19-related Pain and Cough

By Sinan Pektas, Canan Gursoy, Semra Gumus Demirbilek

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Peer-assisted Learning (PAL) as an Instructional Tool in Dental Interns in Corona Virus Disease (COVID-19) Scenario

By Thorakkal Shamim

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Delirium in COVID-19: “New Normal” for Care of Older Adults

By Sadaf Sheikh

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Nasopharyngeal Swab Collection Methods for COVID-19: Suggestions from COVID-19 Diagnosticians

By Sadaf Sheikh

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How COVID (Pandemics) Impacted Training of Medical Students, Trainees, and Residents?

By Seema Rawat, Pankaj Kumar Sharma, Amit Narang

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Thrombotic Thrombocytopenia and Central Venous Sinus Thrombosis Post - COVID-19 Vaccination and its Treatment with Heparin Alternatives

By Sadaf Sheikh

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Risk of Invasive Fungal Infections and Osteonecrosis of Jaw in Patients Exposed to Current Therapeutic Drugs for COVID-19

By Muhammad Adil Asim

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Patient with Profound Anemia due to Hemorrhoids during the Pandemic Period

By Serdar Ozdemir

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Challenges in the Management of Clubfoot in COVID-19 Pandemic

By Pankaj Kumar Sharma, Vivek Tiwari

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Re-Prealbumin: A New Biomarker for Predicting Prognosis in Patients with Severe COVID-19

By Serdar Ozdemir, Kamil Kokulu

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Point of Care Ultrasound: Use it to its Full Potential in COVID-19 Pandemic

By Sadaf Sheikh, Saif Alghafri

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